PMID- 17184205
OWN - NLM
STAT- MEDLINE
DCOM- 20070215
LR  - 20091119
IS  - 1462-2416 (Print)
IS  - 1462-2416 (Linking)
VI  - 7
IP  - 8
DP  - 2006 Dec
TI  - Overview of the pharmacoeconomics of pharmacogenetics.
PG  - 1175-84
AB  - Pharmacoeconomics and pharmacogenetics are two fields converging together as it 
      is increasingly recognized that genetic markers predicting efficacy and toxicity 
      to drugs can cost-effectively improve patient care. While pharmacogenetics aims 
      at identifying genetic markers underlying the response to drugs, 
      pharmacoeconomics aims at delivering healthcare cost-effectively. Several studies 
      have investigated the potential cost-effectiveness of pharmacogenetic-based 
      approaches. Recent evidences include screening for thiopurine methyltransferase 
      gene polymorphisms to prevent azathioprine-induced myelosuppression, or screening 
      for human leukocyte antigen (HLA)B5701 to prevent hypersensitivity reactions to 
      abacavir therapy. Furthermore, examples suggesting a cost-effectiveness of 
      markers predicting drug efficacy include screening the angiotensin-converting 
      enzyme gene polymorphisms for statins therapy, the alpha-adducin gene variant for 
      diuretic therapy and the assessment of human epidermal growth factor receptor 
      (HER2) expression for trastuzumab therapy. However, thus far, all these 
      pharmacoeconomic analyses are exploratory and validations in prospective 
      randomized clinical trials are warranted.
FAU - Dervieux, Thierry
AU  - Dervieux T
AD  - Proprius Pharmaceuticals, 12264 El Camino Real, Suite 300, San Diego, CA 
      92130-3062, USA. tdervieux@propriuspharma.com
FAU - Bala, Mohan V
AU  - Bala MV
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Drug Therapy/economics/methods
MH  - *Economics, Pharmaceutical
MH  - Genetic Testing/*economics
MH  - Humans
MH  - *Pharmacogenetics/economics/methods
RF  - 50
EDAT- 2006/12/23 09:00
MHDA- 2007/02/16 09:00
CRDT- 2006/12/23 09:00
PHST- 2006/12/23 09:00 [pubmed]
PHST- 2007/02/16 09:00 [medline]
PHST- 2006/12/23 09:00 [entrez]
AID - 10.2217/14622416.7.8.1175 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2006 Dec;7(8):1175-84. doi: 10.2217/14622416.7.8.1175.