PMID- 17185611
OWN - NLM
STAT- MEDLINE
DCOM- 20070801
LR  - 20220309
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 25
IP  - 4
DP  - 2007 Apr
TI  - Human leukocyte antigen matching estimations in a hypothetical bank of human 
      embryonic stem cell lines in the Japanese population for use in cell 
      transplantation therapy.
PG  - 983-5
AB  - Human embryonic stem (hES) cell lines are of great potential in cell 
      transplantation therapy. However, recipients of such allogeneic transplants 
      probably need treatment with immunosuppressants. Recently, Taylor et al. [Lancet 
      2005;366:2019-2025] proposed banking of hES cell lines and estimated the required 
      number of hES cell lines for beneficial human leukocyte antigen (HLA) matching in 
      the U.K. population. Here, we carried out such an estimation in the Japanese 
      population. We calculated the proportion of patients who can find at least one 
      HLA-matched donor at three loci of HLA-A, -B, and -DR. With a bank of hES cell 
      lines from 170 randomly selected donated embryos, 80% of patients were expected 
      to find at least one hES cell line with a single mismatch at one HLA locus or a 
      better match. Furthermore, 80% of patients are expected to find at least one 
      donor with complete matching at the three HLA loci if parthenogenetic homozygous 
      hES cell lines are established from 55 randomly selected donated oocytes. The 
      relatively low ethnic diversity of the Japanese population may have resulted in a 
      high success rate in beneficial matching. Moreover, parthenogenetic hES cell 
      lines can greatly reduce the number required for a higher degree of HLA matching.
FAU - Nakajima, Fumiaki
AU  - Nakajima F
AD  - Research and Development Department, Central Blood Institute, Japanese Red Cross 
      Society, Tokyo, Japan.
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
FAU - Nakatsuji, Norio
AU  - Nakatsuji N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061221
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Cell Line
MH  - *Cord Blood Stem Cell Transplantation
MH  - Embryonic Stem Cells/*immunology
MH  - Family
MH  - Female
MH  - HLA Antigens/*analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Japan
MH  - Male
MH  - Parthenogenesis
MH  - *Stem Cell Transplantation
MH  - Tissue Banks
EDAT- 2006/12/23 09:00
MHDA- 2007/08/02 09:00
CRDT- 2006/12/23 09:00
PHST- 2006/12/23 09:00 [pubmed]
PHST- 2007/08/02 09:00 [medline]
PHST- 2006/12/23 09:00 [entrez]
AID - 2006-0566 [pii]
AID - 10.1634/stemcells.2006-0566 [doi]
PST - ppublish
SO  - Stem Cells. 2007 Apr;25(4):983-5. doi: 10.1634/stemcells.2006-0566. Epub 2006 Dec 
      21.