PMID- 17186853
OWN - NLM
STAT- MEDLINE
DCOM- 20070109
LR  - 20200422
IS  - 0891-6640 (Print)
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Linking)
VI  - 20
IP  - 6
DP  - 2006 Nov-Dec
TI  - Myeloma-related disorders in cats commonly present as extramedullary neoplasms in 
      contrast to myeloma in human patients: 24 cases with clinical follow-up.
PG  - 1376-83
AB  - BACKGROUND: Myeloma-related disorders (MRD) are rare neoplasms of plasma cells. 
      Published case reports describe a diversity of clinical presentations with 
      confusing terminology and diagnostic criteria as a consequence of the assumption 
      that MRD in cats are analogous to those in dogs or humans. OBJECTIVE: The aim of 
      the study was to describe clinical, clinicopathologic and imaging findings, 
      response to treatment, survival and possible associations with other diseases or 
      vaccination in a large case series. A priori hypotheses were that cats with MRD 
      commonly present with extramedullary involvement and uncommonly have radiographic 
      bone lesions, in contrast to human patients. ANIMALS: Twenty-four cats with MRD 
      confirmed by cytology or histopathology and immunohistochemistry. METHOD: A 
      multicenter retrospective study was performed. RESULTS: Two types of clinical 
      presentation were observed. The first group (n = 17) had neoplasia involving 
      abdominal organs, bone marrow, or both. All developed systemic clinical signs and 
      paraproteinemia. Five of 7 cats that received chemotherapy improved clinically or 
      had decreased serum globulin concentration (median survival, 12.3 months; range, 
      8.5-22 months). The second group comprised 7 cats with skin masses, 2 of which 
      were paraproteinemic and developed rapidly worsening systemic signs. In cats 
      without systemic signs, excision of the skin masses appeared to be associated 
      with prolonged survival (up to 2.4 years). Cats with MRD commonly presented with 
      extramedullary involvement (67%), versus humans with MRD (5%) (P < .001), and 
      uncommonly presented with radiographic bone lesions (8%) versus humans with MRD 
      (80%) (P < .001). CONCLUSIONS: Radiographic bone lesions are uncommon in cats 
      with MRD and extramedullary presentation is common, relative to human myeloma.
FAU - Mellor, Paul J
AU  - Mellor PJ
AD  - Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. 
      p.j.mellor.02@cantab.net
FAU - Haugland, Sean
AU  - Haugland S
FAU - Murphy, Sue
AU  - Murphy S
FAU - Smith, Ken C
AU  - Smith KC
FAU - Holloway, Andrew
AU  - Holloway A
FAU - Archer, Joy
AU  - Archer J
FAU - Powell, Roger M
AU  - Powell RM
FAU - Polton, Gerry A
AU  - Polton GA
FAU - Tasker, Severine
AU  - Tasker S
FAU - McCormick, David
AU  - McCormick D
FAU - Tempest, Michelle E
AU  - Tempest ME
FAU - McNeil, Pauline E
AU  - McNeil PE
FAU - Scase, Timothy J
AU  - Scase TJ
FAU - Knott, Chris D
AU  - Knott CD
FAU - Bonfanti, Ugo
AU  - Bonfanti U
FAU - Villiers, Elizabeth J
AU  - Villiers EJ
FAU - Argyle, David J
AU  - Argyle DJ
FAU - Herrtage, Michael E
AU  - Herrtage ME
FAU - Day, Michael J
AU  - Day MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
SB  - IM
MH  - Animals
MH  - Bone and Bones/diagnostic imaging/pathology
MH  - Cat Diseases/*diagnosis/pathology
MH  - Cats
MH  - Diagnosis, Differential
MH  - Dogs
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Myeloma/diagnosis/pathology/*veterinary
MH  - Organ Specificity
MH  - Radiography
MH  - Retrospective Studies
MH  - Sarcoma, Myeloid/diagnosis/pathology/*veterinary
MH  - Species Specificity
MH  - Survival Analysis
PMC - PMC7166647
EDAT- 2006/12/26 09:00
MHDA- 2007/01/11 09:00
PMCR- 2020/04/19
CRDT- 2006/12/26 09:00
PHST- 2006/12/26 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/12/26 09:00 [entrez]
PHST- 2020/04/19 00:00 [pmc-release]
AID - JVIM1376 [pii]
AID - 10.1892/0891-6640(2006)20[1376:mdiccp]2.0.co;2 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2006 Nov-Dec;20(6):1376-83. doi: 
      10.1892/0891-6640(2006)20[1376:mdiccp]2.0.co;2.