PMID- 17187019
OWN - NLM
STAT- MEDLINE
DCOM- 20070215
LR  - 20070101
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 27
IP  - 6
DP  - 2006 Dec
TI  - Plasma nerve growth factor (NGF) and inflammatory cytokines (IL-6 and MCP-1) in 
      young and adult subjects with Down syndrome: an interesting pathway.
PG  - 773-8
AB  - OBJECTIVES: Down's syndrome (DS) is the most frequent chromosomal aberration in 
      men and it is invariably associated with mental retardation. MATERIAL AND 
      METHODS: Plasma levels of nerve growth factor (NGF), interleukin-6 (IL-6), and 
      monocyte chemoattractant protein-1 (MCP-1) from non demented DS subjects of three 
      different age-cohorts (2-14 years; 20-50 yrs; >60 yrs) and healthy controls were 
      measured. No clinical and sub-clinical inflammation was apparent in DS patients. 
      RESULTS: Plasma levels of NGF were higher in children, adult and old DS subjects 
      than in controls. However, a significant age-related decrease of NGF levels was 
      present in DS subjects. Serum levels of IL-6 and MCP-1 were also increased in DS 
      children and adults, but not in older DS patients. CONCLUSIONS: High levels of 
      circulating NGF might protect DS from clinical complications of atherosclerosis. 
      However, the striking decrement of peripheral NGF levels with advancing age may 
      predispose DS to clinical manifestation of dementia after adulthood.
FAU - Corsi, Massimiliano M
AU  - Corsi MM
AD  - Institute of General Pathology, Laboratory of Clinical Pathology, Medical 
      Faculty, University of Milan, Italy. mmcorsi@unimi.it
FAU - Dogliotti, Giada
AU  - Dogliotti G
FAU - Pedroni, Francesca
AU  - Pedroni F
FAU - Palazzi, Elisa
AU  - Palazzi E
FAU - Magni, Paolo
AU  - Magni P
FAU - Chiappelli, Martina
AU  - Chiappelli M
FAU - Licastro, Federico
AU  - Licastro F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aging/*blood
MH  - Atherosclerosis/blood/complications
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Child
MH  - Child, Preschool
MH  - Down Syndrome/*blood/complications
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/*blood
MH  - Statistics, Nonparametric
EDAT- 2006/12/26 09:00
MHDA- 2007/02/16 09:00
CRDT- 2006/12/26 09:00
PHST- 2006/09/08 00:00 [received]
PHST- 2006/10/23 00:00 [accepted]
PHST- 2006/12/26 09:00 [pubmed]
PHST- 2007/02/16 09:00 [medline]
PHST- 2006/12/26 09:00 [entrez]
AID - NEL270606A12 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2006 Dec;27(6):773-8.