PMID- 17187383
OWN - NLM
STAT- MEDLINE
DCOM- 20070321
LR  - 20171116
IS  - 1542-9733 (Print)
IS  - 1542-9733 (Linking)
VI  - 80
IP  - 1
DP  - 2007 Feb
TI  - Developmental toxic effects of antifungal flusilazole administered by gavage to 
      mice.
PG  - 12-7
AB  - BACKGROUND: The developmental toxicity of flusilazole was studied in CD-1 mice 
      after oral administration. METHODS: Pregnant mice were given flusilazole at doses 
      of 0 (corn oil), 10, 20, and 40 mg/kg/day, by gavage, on gestational days (GD) 
      6-15. RESULTS: Maternal toxicity, as evidenced by reduction in body weight gain 
      and signs of toxicity, was observed at the middle- and high-dose groups. No 
      significant incidence of resorptions or death was observed in any of dose groups. 
      There was a pronounced reduction in fetal weight, which was significantly lower 
      than control from 20 and 40 mg/kg/day. There was no significant increase in the 
      incidence of fetuses with external or visceral malformations in any of dose 
      groups, but there was a significant increase in the incidence of skeletal 
      malformations was observed at 20 and 40 mg/kg/day. CONCLUSIONS: The results of 
      this study reported marked maternal toxicity, growth retardation, and skeletal 
      abnormalities in the mid- and high-dose groups. It seems likely that marked 
      maternal toxicity contributed to the observed alterations in fetal growth 
      retardation and skeletal development. The no-observed-effect level in the present 
      study for maternal and developmental toxicity was 10 mg/kg/day.
CI  - (c) 2006 Wiley-Liss, Inc.
FAU - Farag, Amina T
AU  - Farag AT
AD  - Department of Pesticide Chemistry and Toxicology, Faculty of Agriculture, 
      Alexandria University, Egypt. aminafarag2002@yahoo.com
FAU - Ibrahim, Hala H
AU  - Ibrahim HH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Birth Defects Res B Dev Reprod Toxicol
JT  - Birth defects research. Part B, Developmental and reproductive toxicology
JID - 101155115
RN  - 0 (Antifungal Agents)
RN  - 0 (Silanes)
RN  - 0 (Triazoles)
RN  - F3WG2VVD87 (flusilazole)
SB  - IM
MH  - *Abnormalities, Drug-Induced
MH  - Animals
MH  - Antifungal Agents/*toxicity
MH  - Body Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetus/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Silanes/administration & dosage/pharmacokinetics/*toxicity
MH  - Triazoles/administration & dosage/pharmacokinetics/*toxicity
EDAT- 2006/12/26 09:00
MHDA- 2007/03/22 09:00
CRDT- 2006/12/26 09:00
PHST- 2006/12/26 09:00 [pubmed]
PHST- 2007/03/22 09:00 [medline]
PHST- 2006/12/26 09:00 [entrez]
AID - 10.1002/bdrb.20098 [doi]
PST - ppublish
SO  - Birth Defects Res B Dev Reprod Toxicol. 2007 Feb;80(1):12-7. doi: 
      10.1002/bdrb.20098.