PMID- 17187610
OWN - NLM
STAT- MEDLINE
DCOM- 20070412
LR  - 20131121
IS  - 0803-5253 (Print)
IS  - 0803-5253 (Linking)
VI  - 96
IP  - 1
DP  - 2007 Jan
TI  - Improvement of the eradication rate of Helicobacter pylori gastritis in children 
      is by adjunction of omeprazole to a dual antibiotherapy.
PG  - 82-6
AB  - AIM: The possible improvement of efficacy and tolerability of a 7-day dual 
      antibiotherapy amoxicillin-clarithromycin (AC) on the eradication of Helicobacter 
      pylori (H. pylori) gastritis in children by the adjunction of omeprazole (OAC) 
      was studied. METHODS: Forty-six children presenting with H. pylori gastritis, 
      assessed at inclusion by endoscopy, H. pylori urease test, histology and/or 
      culture were randomised to a twice-daily regimen of AC or OAC. A (13)C-urease 
      breath test was performed 4-6 weeks after the end of the treatment period to 
      evaluate H. pylori eradication. RESULTS: A larger proportion of patients was H. 
      pylori negative (69%) in the OAC regimen treatment 4-6 weeks after eradication 
      treatment compared with those who received dual AC therapy (15%). A total of 
      seven patients (three in the OAC and four in the AC group) reported adverse 
      events (AEs). Only vomiting was reported in more than one patient (one in each 
      treatment regimen) and only one AE was severe (urticaria: in the OAC group, but 
      considered not related to treatment). CONCLUSION: A larger eradication rate of H. 
      pylori was obtained in the triple OAC group than in the dual AC group. Both 
      therapy regimens can be safely administered to children for 7 days.
FAU - Cadranel, S
AU  - Cadranel S
AD  - Queen Fabiola Children's Hospital, Brussels, Belgium.
FAU - Bontemps, P
AU  - Bontemps P
FAU - Van Biervliet, S
AU  - Van Biervliet S
FAU - Alliet, P
AU  - Alliet P
FAU - Lauvau, D
AU  - Lauvau D
FAU - Vandenhoven, G
AU  - Vandenhoven G
FAU - Vandenplas, Y
AU  - Vandenplas Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Ulcer Agents)
RN  - 804826J2HU (Amoxicillin)
RN  - EC 3.5.1.5 (Urease)
RN  - H1250JIK0A (Clarithromycin)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Adolescent
MH  - Amoxicillin/therapeutic use
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Breath Tests
MH  - Child
MH  - Child, Preschool
MH  - Clarithromycin/therapeutic use
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gastritis/*drug therapy/*microbiology
MH  - Helicobacter Infections/diagnosis/*drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Male
MH  - Omeprazole/*therapeutic use
MH  - Treatment Outcome
MH  - Urease/metabolism
EDAT- 2006/12/26 09:00
MHDA- 2007/04/14 09:00
CRDT- 2006/12/26 09:00
PHST- 2006/12/26 09:00 [pubmed]
PHST- 2007/04/14 09:00 [medline]
PHST- 2006/12/26 09:00 [entrez]
AID - APA011 [pii]
AID - 10.1111/j.1651-2227.2006.00011.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2007 Jan;96(1):82-6. doi: 10.1111/j.1651-2227.2006.00011.x.