PMID- 1718855
OWN - NLM
STAT- MEDLINE
DCOM- 19911206
LR  - 20181113
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 74
IP  - 1
DP  - 1991 Sep
TI  - Murine anti-human IL-6 monoclonal antibody prolongs the half-life in circulating 
      blood and thus prolongs the bioactivity of human IL-6 in mice.
PG  - 55-9
AB  - Human interleukin-6 (hIL-6) injected into mice increases antigen-specific 
      antibody production. In the present study, we examined the possibility that 
      anti-hIL-6 murine monoclonal antibody (MH-166) could neutralize this hIL-6 
      activity in vivo. Although MH166 completely neutralized hIL-6 activity in vitro, 
      treatment in vivo with hIL-6 and MH166 combined unexpectedly increased both 
      anti-dinitrophenyl (DNP) and anti-sheep red blood cell (SRBC) antibody production 
      more than treatment with IL-6 alone did. To explain this phenomenon, the serum 
      hIL-6 level was monitored following the MH166 administration. The hIL-6 level was 
      significantly higher in the mice treated with both hIL-6 and MH166 than in the 
      mice treated with hIL-6 alone during the 24 hr following hIL-6 administration. 
      These results indicate that MH166 prolongs half-life of a xenogeneic hIL-6.
FAU - Mihara, M
AU  - Mihara M
AD  - Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd, Shizuoka, 
      Japan.
FAU - Koishihara, Y
AU  - Koishihara Y
FAU - Fukui, H
AU  - Fukui H
FAU - Yasukawa, K
AU  - Yasukawa K
FAU - Ohsugi, Y
AU  - Ohsugi Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Dinitrophenols)
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*immunology
MH  - Antibody Formation/*drug effects
MH  - Dinitrophenols/immunology
MH  - Epitopes/immunology
MH  - Female
MH  - Half-Life
MH  - Humans
MH  - Immunoglobulin G/biosynthesis
MH  - Immunoglobulin M/biosynthesis
MH  - Interleukin-6/immunology/*pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
PMC - PMC1384671
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
PMCR- 1992/09/01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
PHST- 1992/09/01 00:00 [pmc-release]
PST - ppublish
SO  - Immunology. 1991 Sep;74(1):55-9.