PMID- 17188671
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20141120
IS  - 0009-2797 (Print)
IS  - 0009-2797 (Linking)
VI  - 165
IP  - 2
DP  - 2007 Jan 30
TI  - Oxalate modulates thiobarbituric acid reactive species (TBARS) production in 
      supernatants of homogenates from rat brain, liver and kidney: effect of diphenyl 
      diselenide and diphenyl ditelluride.
PG  - 87-98
AB  - The aim of this paper was to investigate the mechanism(s) involved in the sodium 
      oxalate pro-oxidative activity in vitro and the potential protection by diphenyl 
      diselenide ((PhSe)(2)) and diphenyl ditelluride ((PhTe)(2)) using supernatants of 
      homogenates from brain, liver and kidney. Oxalate causes a significant increase 
      in the TBARS (thiobarbituric acid reactive species) production up to 4mmol/l and 
      it had antioxidant activity from 8 to 16mmol/l in the brain and liver. Oxalate 
      had no effect in kidney homogenates. The difference among tissues may be related 
      to the formation of insoluble crystal of oxalate in kidney, but not in liver and 
      brain homogenates. (PhSe)(2) and (PhTe)(2) reduced both basal and oxalate-induced 
      TBARS in rat brain homogenates, whereas in liver homogenates they were 
      antioxidant only on oxalate-induced TBARS production. (PhSe)(2) showed a modest 
      effect on renal TBARS production, whereas (PhTe)(2) did not modulate TBARS in 
      kidney preparations. Oxalate at 2mmol/l did not change deoxyribose degradation 
      induced by Fe(2+) plus H(2)O(2), whereas at 20mmol/l it significantly prevents 
      its degradation. Oxalate (up to 4mmol/l) did not alter iron 
      (10micromol/l)-induced TBARS production in the brain preparations, whereas at 
      8mmol/l onwards it prevents iron effect. In liver preparations, oxalate amplifies 
      iron pro-oxidant activity up to 4mmol/l, preventing iron-induced TBARS production 
      at 16mmol/l onwards. These results support the antioxidant effect of 
      organochalcogens against oxalate-induced TBARS production. In addition, our 
      results suggest that oxalate pro- and antioxidant activity in vitro could be 
      related to its interactions with iron ions.
FAU - Puntel, Robson Luiz
AU  - Puntel RL
AD  - Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade 
      Federal de Santa Maria, Campus UFSM, Santa Maria, RS 97105-900, Brazil.
FAU - Roos, Daniel Henrique
AU  - Roos DH
FAU - Paixao, Marcio Weber
AU  - Paixao MW
FAU - Braga, Antonio Luiz
AU  - Braga AL
FAU - Zeni, Gilson
AU  - Zeni G
FAU - Nogueira, Cristina Wayne
AU  - Nogueira CW
FAU - Rocha, Joao Batista Teixeira
AU  - Rocha JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061123
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Antioxidants)
RN  - 0 (Benzene Derivatives)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (Oxalates)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (diphenylditelluride)
RN  - 1666-13-3 (diphenyldiselenide)
RN  - 533-67-5 (Deoxyribose)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Benzene Derivatives/pharmacology
MH  - Brain/*drug effects/metabolism
MH  - Deoxyribose/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Antagonism
MH  - In Vitro Techniques
MH  - Iron/metabolism/pharmacology
MH  - Kidney/*drug effects/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Organometallic Compounds/*pharmacology
MH  - Organoselenium Compounds/pharmacology
MH  - Oxalates/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Thiobarbituric Acid Reactive Substances/*metabolism
EDAT- 2006/12/26 09:00
MHDA- 2007/03/14 09:00
CRDT- 2006/12/26 09:00
PHST- 2006/07/31 00:00 [received]
PHST- 2006/11/03 00:00 [revised]
PHST- 2006/11/09 00:00 [accepted]
PHST- 2006/12/26 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/12/26 09:00 [entrez]
AID - S0009-2797(06)00326-7 [pii]
AID - 10.1016/j.cbi.2006.11.003 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2007 Jan 30;165(2):87-98. doi: 10.1016/j.cbi.2006.11.003. 
      Epub 2006 Nov 23.