PMID- 17188789 OWN - NLM STAT- MEDLINE DCOM- 20070424 LR - 20071115 IS - 0278-5846 (Print) IS - 0278-5846 (Linking) VI - 31 IP - 2 DP - 2007 Mar 30 TI - Facial expressivity during the clinical interview as a predictor functional disability in schizophrenia. a pilot study. PG - 475-81 AB - Despite the central role of nonverbal behavior in regulating social interactions, its relationship to functional disability in schizophrenia has received little empirical attention. This study aimed at assessing the relationship of patients' spontaneous facial expressivity during the clinical interview to clinician-rated and self-reported measures of functional disability. The nonverbal behavior of 28 stabilized patients with schizophrenia was analyzed by using the Ethological Coding System for Interviews (ECSI). Functional disability was assessed using the Global Assessment of Functioning (GAF) scale and the Sheehan Disability Scale (DISS). Partial correlation analysis controlling for the confounding effects of neuroleptic treatment showed that facial expressivity was correlated with the GAF score (r=0.42, P=0.03) and the scores on the subscales of the DISS measuring work (r=-0.52, P=0.005) and social (r=-0.50, P=0.007) disability. In a multiple regression model, nonverbal behavior explained variation in patients' work and social disability better than negative symptoms. The results of this pilot study suggest that deficits in encoding affiliative signals may play a role in determining or aggravating functional disability in schizophrenia. One clinical implication of this finding is that remediation training programs designed to improve nonverbal communication could also serve as a useful adjunct for improving work and social functioning in patients with schizophrenia. FAU - Troisi, Alfonso AU - Troisi A AD - Department of Neurosciences, University of Rome Tor Vergata, via G.A. Guattani, 00161, Rome, Italy. alfonso.troisi@uniroma2.it FAU - Pompili, Enrico AU - Pompili E FAU - Binello, Luigi AU - Binello L FAU - Sterpone, Alessandro AU - Sterpone A LA - eng PT - Journal Article DEP - 20061226 PL - England TA - Prog Neuropsychopharmacol Biol Psychiatry JT - Progress in neuro-psychopharmacology & biological psychiatry JID - 8211617 SB - IM MH - Adult MH - *Disability Evaluation MH - *Facial Expression MH - Female MH - Humans MH - Interviews as Topic MH - Male MH - Middle Aged MH - Nonverbal Communication MH - Pilot Projects MH - Predictive Value of Tests MH - Psychiatric Status Rating Scales MH - Schizophrenia/*diagnosis/*physiopathology MH - *Schizophrenic Psychology EDAT- 2006/12/26 09:00 MHDA- 2007/04/25 09:00 CRDT- 2006/12/26 09:00 PHST- 2006/04/23 00:00 [received] PHST- 2006/11/11 00:00 [revised] PHST- 2006/11/14 00:00 [accepted] PHST- 2006/12/26 09:00 [pubmed] PHST- 2007/04/25 09:00 [medline] PHST- 2006/12/26 09:00 [entrez] AID - S0278-5846(06)00410-6 [pii] AID - 10.1016/j.pnpbp.2006.11.016 [doi] PST - ppublish SO - Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):475-81. doi: 10.1016/j.pnpbp.2006.11.016. Epub 2006 Dec 26.