PMID- 17189225
OWN - NLM
STAT- MEDLINE
DCOM- 20070221
LR  - 20181113
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 84
IP  - 5
DP  - 2006 Dec
TI  - Human herpesvirus 6 meningoencephalitis in allogeneic hematopoietic stem cell 
      transplant recipients.
PG  - 432-7
AB  - We retrospectively investigated the clinical characteristics of human herpesvirus 
      6 (HHV-6) meningoencephalitis within 100 days after allogeneic hematopoietic stem 
      cell transplantation (HSCT). Of 1148 patients who received transplants between 
      January 1999 and December 2003, 11 patients (0.96%) with HHV-6 
      meningoencephalitis were identified. Ten of 11 recipients received hematopoietic 
      stem cells from donors other than HLA-identical siblings. Confusion was the most 
      frequent central nervous system (CNS) symptom, and a skin rash with high-grade 
      fever preceded the CNS symptoms in 9 patients. Magnetic resonance imaging of the 
      brain showed an abnormal increased T2 signal in the hypothalamus of 5 patients. 
      Eight patients were treated with ganciclovir, and an improvement of CNS symptoms 
      was obtained in 3 patients; 3 patients treated with acyclovir showed no 
      improvement. Improvement in the meningoencephalitis seemed less frequent in 
      patients with abnormal findings in the hypothalamus than in those without such 
      findings. Because the symptoms of HHV-6 meningoencephalitis mimicked those of 
      cyclosporine- or tacrolimus-induced encephalopathy, the drugs were withdrawn at 
      the onset of CNS symptoms in 10 patients, resulting in the development of grade 
      IV graft-versus-host disease (GVHD) in 5 patients. Three patients died of HHV-6 
      meningoencephalitis, and 6 died of other causes, including GVHD. In conclusion, 
      HHV-6 meningoencephalitis is a rare but potentially life-threatening complication 
      in patients who undergo allogeneic HSCT. Careful assessment of the clinical 
      findings and the brain may allow early and precise diagnosis of HHV-6 
      meningoencephalitis and contribute to improving its prognosis.
FAU - Fujimaki, Katsumichi
AU  - Fujimaki K
AD  - Department of Internal Medicine and Clinical Immunology, Yokohama City 
      University, Graduate School of Medicine, Yokohama, Japan. 
      kfujimaki@cancer.livedoor.com
FAU - Mori, Takehiko
AU  - Mori T
FAU - Kida, Aiko
AU  - Kida A
FAU - Tanaka, Masatsugu
AU  - Tanaka M
FAU - Kawai, Nobutaka
AU  - Kawai N
FAU - Matsushima, Takafumi
AU  - Matsushima T
FAU - Kishi, Kenji
AU  - Kishi K
FAU - Fujisawa, Shin
AU  - Fujisawa S
FAU - Sakura, Tohru
AU  - Sakura T
FAU - Yokota, Akira
AU  - Yokota A
FAU - Kanda, Yoshinobu
AU  - Kanda Y
FAU - Taguchi, Jun
AU  - Taguchi J
FAU - Akiyama, Hideki
AU  - Akiyama H
FAU - Kanamori, Heiwa
AU  - Kanamori H
FAU - Maruta, Atsuo
AU  - Maruta A
FAU - Okamoto, Shinichiro
AU  - Okamoto S
FAU - Sakamaki, Hisashi
AU  - Sakamaki H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Antiviral Agents)
RN  - P9G3CKZ4P5 (Ganciclovir)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antiviral Agents/administration & dosage
MH  - Child
MH  - Female
MH  - Ganciclovir/administration & dosage
MH  - Graft vs Host Disease/diagnosis/diagnostic imaging/drug 
      therapy/etiology/mortality
MH  - Hematologic Neoplasms/diagnostic imaging/mortality/therapy
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Hypothalamus/diagnostic imaging/virology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Meningoencephalitis/diagnosis/diagnostic imaging/drug therapy/mortality/virology
MH  - Middle Aged
MH  - Prognosis
MH  - Radiography
MH  - Retrospective Studies
MH  - *Roseolovirus Infections/diagnosis/diagnostic imaging/drug 
      therapy/etiology/mortality
MH  - Transplantation, Homologous
EDAT- 2006/12/26 09:00
MHDA- 2007/02/22 09:00
CRDT- 2006/12/26 09:00
PHST- 2006/12/26 09:00 [pubmed]
PHST- 2007/02/22 09:00 [medline]
PHST- 2006/12/26 09:00 [entrez]
AID - AT763K7353613834 [pii]
AID - 10.1532/IJH97.06072 [doi]
PST - ppublish
SO  - Int J Hematol. 2006 Dec;84(5):432-7. doi: 10.1532/IJH97.06072.