PMID- 17189822
OWN - NLM
STAT- MEDLINE
DCOM- 20070222
LR  - 20171116
IS  - 0891-5849 (Print)
IS  - 0891-5849 (Linking)
VI  - 42
IP  - 2
DP  - 2007 Jan 15
TI  - The cellular basis for diverse responses to oxygen.
PG  - 165-74
AB  - Mammalian cells have divergent responses to varying oxygen levels. Cells exposed 
      to low oxygen levels (hypoxia) activate the transcription factor 
      hypoxia-inducible factor-1 (HIF-1) as an adaptive response. Cells exposed to 
      hypoxia do not undergo senescence or cell death and do not diminish ATP levels. 
      By contrast, cells exposed to high oxygen levels (hyperoxia) undergo senescence 
      and cell death and decrease their ATP levels, yet do not activate HIF-1. Despite 
      these divergent responses with respect to senescence, cell death, metabolism, and 
      gene expression, the signaling events in both systems are mediated by the 
      generation of mitochondrial-derived reactive oxygen species (ROS). This 
      perspective reviews the role of signaling through mitochondrial ROS in hypoxic 
      and hyperoxic environments.
FAU - Chandel, Navdeep S
AU  - Chandel NS
AD  - Department of Medicine and Department of Cell & Molecular Biology, Northwestern 
      University, McGaw Pavilion M-334, 240 East Huron Avenue, Chicago, IL 60611, USA.
FAU - Budinger, G R Scott
AU  - Budinger GR
LA  - eng
GR  - AG027093/AG/NIA NIH HHS/United States
GR  - ES013995/ES/NIEHS NIH HHS/United States
GR  - GM060472/GM/NIGMS NIH HHS/United States
GR  - HL071643/HL/NHLBI NIH HHS/United States
GR  - HL09315/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20061028
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Reactive Oxygen Species)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Cell Hypoxia/physiology
MH  - Cellular Senescence/physiology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/metabolism
MH  - Mitochondria/*metabolism
MH  - Oxygen/*metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction/*immunology
RF  - 47
EDAT- 2006/12/27 09:00
MHDA- 2007/02/23 09:00
CRDT- 2006/12/27 09:00
PHST- 2006/05/05 00:00 [received]
PHST- 2006/09/27 00:00 [revised]
PHST- 2006/10/24 00:00 [accepted]
PHST- 2006/12/27 09:00 [pubmed]
PHST- 2007/02/23 09:00 [medline]
PHST- 2006/12/27 09:00 [entrez]
AID - S0891-5849(06)00694-0 [pii]
AID - 10.1016/j.freeradbiomed.2006.10.048 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2007 Jan 15;42(2):165-74. doi: 
      10.1016/j.freeradbiomed.2006.10.048. Epub 2006 Oct 28.