PMID- 17190743
OWN - NLM
STAT- MEDLINE
DCOM- 20070305
LR  - 20191110
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 28
IP  - 4
DP  - 2006
TI  - Inhibition of mite-induced immunoglobulin E synthesis, airway inflammation, and 
      hyperreactivity by herbal medicine STA-1.
PG  - 683-95
AB  - The availability of STA-1 in suppressing allergen-induced immunoglobulin E (IgE) 
      synthesis, airway inflammation and hyperreactivity in a murine model was 
      investigated. The mice were intraperitoneally sensitized with Dermatophagoides 
      pteronyssinus group 5 allergen (Der p 5) and orally treated with 300 mg/kg of 
      STA-1 every other day for 14 days. The Der p 5-specific immunologic responses 
      including changes of specific immunoglobulin G and E, cells in the broncholarvage 
      fluid, and airway hyperreactivity were measured when mice received inhalation 
      challenge with Der p 5 after sensitization for 21 days. By comparing with 
      sham-treated groups, the synthesis of Der p 5-specific IgE was downregulated 
      while the influx of eosinophils and neutrophils in the airway were remarkably 
      reduced. In addition, Der p 5-induced airway hyperreactivity also was 
      significantly eliminated by STA-1 treatment. These results showed that STA-1 
      could effectively suppress the Der p 5-induced allergic reactions, and the 
      availability of STA-1 for the treatment of allergic asthma was demonstrated in 
      this study.
FAU - Chang, Tung-Ti
AU  - Chang TT
AD  - Graduate Institute of Chinese Medical Science, China Medical University, 
      Taichung, Taiwan, Republic of China.
FAU - Huang, Chieh-Chen
AU  - Huang CC
FAU - Hsu, Ching-Hsiang
AU  - Hsu CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Aerosols)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Immunoglobulin G)
RN  - 0 (STA-1 medicine)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aerosols
MH  - Airway Resistance
MH  - Animals
MH  - Antibody Specificity
MH  - Antigens, Dermatophagoides/*immunology
MH  - Asthma/pathology
MH  - Bronchial Hyperreactivity/*drug therapy/etiology
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Cell Count
MH  - Drugs, Chinese Herbal/adverse effects/*therapeutic use/toxicity
MH  - Female
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Inflammation/*drug therapy/etiology
MH  - Lethal Dose 50
MH  - Mice
MH  - Mice, Inbred BALB C
EDAT- 2006/12/28 09:00
MHDA- 2007/03/06 09:00
CRDT- 2006/12/28 09:00
PHST- 2006/12/28 09:00 [pubmed]
PHST- 2007/03/06 09:00 [medline]
PHST- 2006/12/28 09:00 [entrez]
AID - R3372481V23V2591 [pii]
AID - 10.1080/08923970601067409 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2006;28(4):683-95. doi: 10.1080/08923970601067409.