PMID- 17192436
OWN - NLM
STAT- MEDLINE
DCOM- 20070201
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 26
IP  - 52
DP  - 2006 Dec 27
TI  - Single-cell characterization of retrograde signaling by brain-derived 
      neurotrophic factor.
PG  - 13531-6
AB  - Brain-derived neurotrophic factor (BDNF) is a key regulator of hippocampal 
      synaptic plasticity in the developing and adult nervous system. It can be 
      released from pyramidal neuron dendrites in an activity-dependent manner and has 
      therefore been suggested to serve as a signal that provides the retrograde 
      intercellular communication necessary for Hebbian plasticity and 
      hippocampal-dependent learning. Although much has been learned about BDNF 
      function by field stimulation of hippocampal neurons, it is not known whether 
      moderate action potential-independent depolarization of single cells is capable 
      of releasing sufficient BDNF to influence transmission at individual synapses. In 
      this study, we show directly at the single-cell level that such modulation can 
      occur. By using K-252a, anti-BDNF antibody, and interruption of regulated 
      release, we confirm a model in which postsynaptic depolarization elicits 
      calcium-dependent release of BDNF that diffuses retrogradely and enhances 
      presynaptic transmitter release.
FAU - Magby, Jason P
AU  - Magby JP
AD  - Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New 
      Jersey 08854, USA.
FAU - Bi, Caixia
AU  - Bi C
FAU - Chen, Zhe-Yu
AU  - Chen ZY
FAU - Lee, Francis S
AU  - Lee FS
FAU - Plummer, Mark R
AU  - Plummer MR
LA  - eng
GR  - P01 HD023315/HD/NICHD NIH HHS/United States
GR  - R01 NS041310/NS/NINDS NIH HHS/United States
GR  - HD23315/HD/NICHD NIH HHS/United States
GR  - NS041310/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Axonal Transport/*physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - Cells, Cultured
MH  - Female
MH  - Hippocampus/*cytology/metabolism/*physiology
MH  - Membrane Potentials/physiology
MH  - Models, Neurological
MH  - Pregnancy
MH  - Presynaptic Terminals/metabolism/physiology/ultrastructure
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/*physiology
MH  - Synaptic Transmission/genetics/physiology
PMC - PMC6674723
EDAT- 2006/12/29 09:00
MHDA- 2007/02/03 09:00
PMCR- 2007/06/27
CRDT- 2006/12/29 09:00
PHST- 2006/12/29 09:00 [pubmed]
PHST- 2007/02/03 09:00 [medline]
PHST- 2006/12/29 09:00 [entrez]
PHST- 2007/06/27 00:00 [pmc-release]
AID - 26/52/13531 [pii]
AID - 3177814 [pii]
AID - 10.1523/JNEUROSCI.4576-06.2006 [doi]
PST - ppublish
SO  - J Neurosci. 2006 Dec 27;26(52):13531-6. doi: 10.1523/JNEUROSCI.4576-06.2006.