PMID- 17192666
OWN - NLM
STAT- MEDLINE
DCOM- 20070223
LR  - 20181113
IS  - 0895-8696 (Print)
IS  - 0895-8696 (Linking)
VI  - 30
IP  - 1-2
DP  - 2006
TI  - Presynaptic muscarinic control of glutamatergic synaptic transmission.
PG  - 161-4
AB  - The hippocampus receives cholinergic projections from the medial septal nucleus 
      and Broca's diagonal band that terminate in the CA1, CA3, and dentate gyrus 
      regions (Frotscher and Leranth, 1985). Glutamatergic synapses between CA3 and CA1 
      pyramidal neurons are presynaptically inhibited by acetylcholine (ACh), via 
      activation of muscarinic ACh receptors (mAChRs) at the terminals of Schaffer 
      collaterals (SCs) (Hounsgaard, 1978; Fernandez de Sevilla et al., 2002, 2003). 
      There are two types of SC-CA1 pyramidal neuron synapses. One type, called 
      functional synapse, shows postsynaptic alpha- 
      amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-receptor mediated currents 
      at resting potential (Vm) and both AMPA and N-methyl-D-aspartate receptor 
      (NMDAR)-mediated currents when depolarized. The other type, termed silent 
      synapse, only displays postsynaptic NMDAR-mediated currents at depolarized Vms, 
      but does not respond at the resting Vm (Isaac et al., 1995). Using hippocampal 
      slices obtained from young Wistar rats, we examined the effects of activation of 
      cholinergic afferents at the stratum oriens/alveus on excitatory postsynaptic 
      currents (EPSCs) evoked in CA1 pyramidal neurons by stimulation of SCs. We also 
      tested the action of the nonhydrolyzable cholinergic agonist carbamylcholine 
      chloride (CCh) on EPSCs evoked by minimal stimulation of SCs (which activates a 
      single or very few synapses) in functional and silent synapses.
FAU - Buno, W
AU  - Buno W
AD  - Departamento de Plasticidad Neural, Instituto Cajal, 28002 Madrid, Spain. 
      isrwb14@cajal.csic.es
FAU - Cabezas, C
AU  - Cabezas C
FAU - Fernandez de Sevilla, D
AU  - Fernandez de Sevilla D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Receptors, Muscarinic)
RN  - 8Y164V895Y (Carbachol)
SB  - IM
MH  - Animals
MH  - Carbachol/pharmacology
MH  - Evoked Potentials/physiology
MH  - Hippocampus/*physiology
MH  - Pyramidal Cells/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Muscarinic/*physiology
MH  - Synapses/drug effects/physiology
MH  - Synaptic Transmission/*physiology
EDAT- 2006/12/29 09:00
MHDA- 2007/02/24 09:00
CRDT- 2006/12/29 09:00
PHST- 1999/11/30 00:00 [received]
PHST- 1999/11/30 00:00 [revised]
PHST- 1999/11/30 00:00 [accepted]
PHST- 2006/12/29 09:00 [pubmed]
PHST- 2007/02/24 09:00 [medline]
PHST- 2006/12/29 09:00 [entrez]
AID - JMN:30:1:161 [pii]
AID - 10.1385/JMN:30:1:161 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2006;30(1-2):161-4. doi: 10.1385/JMN:30:1:161.