PMID- 17192952
OWN - NLM
STAT- MEDLINE
DCOM- 20070718
LR  - 20221207
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 144B
IP  - 3
DP  - 2007 Apr 5
TI  - Association study between the TNXB locus and schizophrenia in a Japanese 
      population.
PG  - 305-9
AB  - The chromosome 6p21-24 region, which contains the human leukocyte antigen (HLA) 
      region, has been suggested as an important locus for a susceptibility gene for 
      schizophrenia. Recently, a significant association between schizophrenia and the 
      TNXB locus, located immediately telomeric of the NOTCH4 locus in the HLA region, 
      was observed. Few studies have further investigated the region in schizophrenia. 
      In the present study, we investigated the region in a Japanese population. 
      Subjects included 241 patients with schizophrenia and 290 controls. Twenty-six 
      single nucleotide polymorphisms (SNPs) and the corresponding haplotypes were 
      analyzed. As a result, exactly the same SNPs in the TNXB locus (rs1009382 and 
      rs204887) as in the previous study were associated with schizophrenia (P = 0.034 
      and 0.034, respectively, uncorrected). A SNP (rs2071287) in the NOTCH4 locus and 
      haplotype around it were also suggested to associate with the disease, consistent 
      with another previous study (P = 0.041 and permutation P = 0.024, respectively, 
      uncorrected). Although these associations became insignificant after Bonferroni 
      correction, the findings might provide support for the association of the TNXB 
      locus or its adjacent region of the NOTCH4 locus with schizophrenia.
CI  - (c) 2006 Wiley-Liss, Inc.
FAU - Tochigi, Mamoru
AU  - Tochigi M
AD  - Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 
      Bunkyo, Tokyo, Japan.
FAU - Zhang, Xuan
AU  - Zhang X
FAU - Ohashi, Jun
AU  - Ohashi J
FAU - Hibino, Hiroyuki
AU  - Hibino H
FAU - Otowa, Takeshi
AU  - Otowa T
FAU - Rogers, Mark
AU  - Rogers M
FAU - Kato, Tadafumi
AU  - Kato T
FAU - Okazaki, Yuji
AU  - Okazaki Y
FAU - Kato, Nobumasa
AU  - Kato N
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
FAU - Sasaki, Tsukasa
AU  - Sasaki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (NOTCH4 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptor, Notch4)
RN  - 0 (Receptors, Notch)
RN  - 0 (Tenascin)
RN  - 0 (tenascin X)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - *Gene Frequency
MH  - *Genetic Linkage
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Proto-Oncogene Proteins/genetics
MH  - Receptor, Notch4
MH  - Receptors, Notch/genetics
MH  - Schizophrenia/*genetics
MH  - Tenascin/*genetics
EDAT- 2006/12/29 09:00
MHDA- 2007/07/19 09:00
CRDT- 2006/12/29 09:00
PHST- 2006/12/29 09:00 [pubmed]
PHST- 2007/07/19 09:00 [medline]
PHST- 2006/12/29 09:00 [entrez]
AID - 10.1002/ajmg.b.30441 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2007 Apr 5;144B(3):305-9. doi: 
      10.1002/ajmg.b.30441.