PMID- 17195229
OWN - NLM
STAT- MEDLINE
DCOM- 20070215
LR  - 20151119
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 56
IP  - 1
DP  - 2007 Jan
TI  - A serology-based approach combined with clinical examination of 125 
      Ro/SSA-positive patients to define incidence and prevalence of subacute cutaneous 
      lupus erythematosus.
PG  - 255-64
AB  - OBJECTIVE: To estimate the incidence and prevalence of Ro/SSA-positive subacute 
      cutaneous lupus erythematosus (SCLE) in Stockholm County, Sweden (1.8 million 
      inhabitants) and to investigate the frequency of photosensitivity and other 
      clinical manifestations associated with Ro/SSA autoantibodies. METHODS: 
      Ro/SSA-positive patients in Stockholm were identified via registry-based 
      searches. All patients who tested positive for the presence of Ro/SSA 
      autoantibodies during 1996-2002 (n = 1,323; 85% women) were identified. A 
      questionnaire was sent to all patients still living in Stockholm in 2003 (n = 
      1,048). Patients who reported having skin symptoms and photosensitivity (n = 125) 
      underwent a clinical examination. RESULTS: Of the 741 (71%) of 1,048 
      Ro/SSA-positive patients who responded to the questionnaire, 400 (54%) reported 
      having photosensitivity, and of these patients, 125 agreed to be clinically 
      examined. A diagnosis of LE was confirmed in 59 of the 125 patients (SCLE in 20, 
      systemic LE [SLE] in 33, and chronic CLE in 6). Eighty-six patients reported 
      experiencing symptoms consistent with polymorphous light eruption (PLE). 
      Comorbidities such as cardiovascular disease, autoimmune disease, and other skin 
      diseases were common. The incidence of Ro/SSA-positive SCLE during the study 
      period was estimated to be 0.7 cases per 100,000 persons per year and the 
      prevalence was approximately 6.2-14 in 100,000 persons. CONCLUSION: The incidence 
      of Ro/SSA-positive SCLE in Stockholm County, Sweden is estimated to be 0.7 per 
      100,000 persons per year as compared with an incidence of SLE in Sweden of 4.8 
      per 100,000 persons per year. The prevalence is estimated to be 6.2-14 in 100,000 
      persons. Self-reported photosensitivity commonly corresponds to a history of PLE 
      in Ro/SSA-positive patients, even when the clinical profile of SCLE is absent. 
      Photoprotection should therefore be included in the treatment recommendations for 
      these patients.
FAU - Popovic, Karin
AU  - Popovic K
AD  - Karolinska Institutet, Stockholm, Sweden. karin.popovic@ki.se
FAU - Nyberg, Fredrik
AU  - Nyberg F
FAU - Wahren-Herlenius, Marie
AU  - Wahren-Herlenius M
FAU - Nyberg, Filippa
AU  - Nyberg F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Ribonucleoproteins)
RN  - 0 (SS-A antigen)
SB  - IM
MH  - Age Distribution
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lupus Erythematosus, Cutaneous/*epidemiology/*immunology/pathology
MH  - Male
MH  - Photosensitivity Disorders/epidemiology/immunology/pathology
MH  - Prevalence
MH  - Ribonucleoproteins/*immunology
MH  - Seroepidemiologic Studies
MH  - Sex Distribution
MH  - Surveys and Questionnaires
MH  - Sweden/epidemiology
EDAT- 2006/12/30 09:00
MHDA- 2007/02/16 09:00
CRDT- 2006/12/30 09:00
PHST- 2006/12/30 09:00 [pubmed]
PHST- 2007/02/16 09:00 [medline]
PHST- 2006/12/30 09:00 [entrez]
AID - 10.1002/art.22286 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2007 Jan;56(1):255-64. doi: 10.1002/art.22286.