PMID- 17195895
OWN - NLM
STAT- MEDLINE
DCOM- 20070201
LR  - 20131121
IS  - 0027-2507 (Print)
IS  - 0027-2507 (Linking)
VI  - 73
IP  - 7
DP  - 2006 Nov
TI  - HIV-related pulmonary hypertension.
PG  - 1037-44
AB  - With the availability of better treatment and prophylactic regimens for the 
      infectious complications of human immunodeficiency virus (HIV), the 
      non-infectious complications are gaining greater attention. HIV-related pulmonary 
      arterial hypertension (HIV-PAH) is one of these. The incidence of HIV-PAH is 
      estimated at 0.5% of HIV-infected individuals. The pathogenesis remains unclear. 
      Patients present with symptoms as diverse as progressive shortness of breath, 
      pedal edema, dry cough, fatigue, syncope, as well as chest pain. Chest X-ray 
      always shows cardiomegaly and prominent pulmonary artery, and evidence of right 
      ventricular hypertrophy can be seen from the electrocardiogram. The pulmonary 
      arterial systolic pressure, diastolic pressure and pulmonary vascular resistance 
      from right heart catheterization are increased. There are a few small studies 
      showing the benefit of prostacyclin analog (epoprostenol and iloprost) and 
      bosentan. The role of antiretrovirals remains controversial, as do those of other 
      agents such as calcium channel blockers and anticoagulants. The prognosis of 
      HIV-PAH is grave. Two thirds of HIV-PAH related mortality is usually secondary to 
      consequences of pulmonary hypertension, with the worst survival noted in New York 
      Heart Association (NYHA) functional class III-IV. The probability of survival in 
      one series was 73%, 60% and 47% at one, two and three years, respectively.
FAU - Limsukon, Atikun
AU  - Limsukon A
AD  - Department of Internal Medicine, Bronx Veterans Affairs Medical Center, NY, USA. 
      atikhun@hotmail.com
FAU - Saeed, Ali Imran
AU  - Saeed AI
FAU - Ramasamy, Vimala
AU  - Ramasamy V
FAU - Nalamati, Jhansi
AU  - Nalamati J
FAU - Dhuper, Sunil
AU  - Dhuper S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mt Sinai J Med
JT  - The Mount Sinai journal of medicine, New York
JID - 0241032
RN  - 0 (Vasodilator Agents)
RN  - JED5K35YGL (Iloprost)
SB  - IM
MH  - Disease Progression
MH  - HIV Infections/*complications
MH  - Humans
MH  - Hypertension, Pulmonary/mortality/pathology/physiopathology/therapy/*virology
MH  - Iloprost/therapeutic use
MH  - Prognosis
MH  - Pulmonary Artery/pathology
MH  - Tomography, X-Ray Computed
MH  - Vasodilator Agents/therapeutic use
RF  - 35
EDAT- 2007/01/02 09:00
MHDA- 2007/02/03 09:00
CRDT- 2007/01/02 09:00
PHST- 2007/01/02 09:00 [pubmed]
PHST- 2007/02/03 09:00 [medline]
PHST- 2007/01/02 09:00 [entrez]
PST - ppublish
SO  - Mt Sinai J Med. 2006 Nov;73(7):1037-44.