PMID- 17196935
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20091119
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 353
IP  - 3
DP  - 2007 Feb 16
TI  - Phospholipase Cgamma1 stimulates transcriptional activation of the matrix 
      metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade.
PG  - 611-6
AB  - The phospholipid hydrolase phospholipase Cgamma1 (PLCgamma1) plays a major role 
      in regulation of cell proliferation, development, and cell motility. 
      Overexpression of PLCgamma1 is associated with tumor development, and it is 
      overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein 
      involved in tumor invasion and metastasis. Here, we demonstrate that 
      overexpression of PLCgamma1 stimulates MMP-3 expression at the transcriptional 
      level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that 
      modulation of PLCgamma1 activity might be of value in controlling the activity of 
      MMPs, which are important regulators of invasion and metastasis in malignant 
      tumors.
FAU - Shin, Soon Young
AU  - Shin SY
AD  - Institute of Natural Science and Technology, Hanyang University, Ansan 426-791, 
      South Korea.
FAU - Choi, Ha Young
AU  - Choi HY
FAU - Ahn, Bong-Hyun
AU  - Ahn BH
FAU - Min, Do Sik
AU  - Min do S
FAU - Son, Sang Wook
AU  - Son SW
FAU - Lee, Young Han
AU  - Lee YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061220
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - EC 2.7.11.1 (raf Kinases)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 3.1.4.3 (Phospholipase C gamma)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Cell Movement/physiology
MH  - Cells, Cultured
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Gene Expression Regulation, Enzymologic
MH  - Matrix Metalloproteinase 3/biosynthesis/*genetics
MH  - Mice
MH  - NIH 3T3 Cells
MH  - Phospholipase C gamma/*physiology
MH  - Promoter Regions, Genetic/drug effects
MH  - Protein Kinase C/*metabolism
MH  - Rats
MH  - Signal Transduction/*physiology
MH  - Wound Healing/physiology
MH  - raf Kinases/*metabolism
EDAT- 2007/01/02 09:00
MHDA- 2007/03/14 09:00
CRDT- 2007/01/02 09:00
PHST- 2006/11/15 00:00 [received]
PHST- 2006/12/11 00:00 [accepted]
PHST- 2007/01/02 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2007/01/02 09:00 [entrez]
AID - S0006-291X(06)02720-3 [pii]
AID - 10.1016/j.bbrc.2006.12.064 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 Feb 16;353(3):611-6. doi: 
      10.1016/j.bbrc.2006.12.064. Epub 2006 Dec 20.