PMID- 17196936
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20221207
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 353
IP  - 3
DP  - 2007 Feb 16
TI  - Brain-derived neurotrophic factor and risk of schizophrenia: an association study 
      and meta-analysis.
PG  - 738-43
AB  - Brain-derived neurotrophic factor (BDNF) is the most widely distributed 
      neurotrophin in the central nervous system (CNS), and performs many biological 
      functions such as neural survival, differentiation, and plasticity. Previous 
      studies have suggested that variants in the BDNF gene increase the risk of 
      schizophrenia. In this study, we genotyped one (GT)n dinucleotide repeat and 
      three SNPs (rs6265, rs2030324, and rs2883187) in a Chinese sample (617 cases and 
      672 controls). In addition, we performed an updated meta-analysis based on 16 
      population-based case-control studies examining association between rs6265 and 
      schizophrenia. In single-locus analysis, no significant association was found 
      between BDNF polymorphisms and schizophrenia in our subjects. The meta-analysis 
      based on Asian and Caucasian subjects did not give positive result that rs6265 is 
      associated with schizophrenia. However, haplotype analysis found a common 
      four-locus haplotype is protective against schizophrenia (Case 3.1% vs Control 
      7%, p=0.0011). Our data provides evidence that BDNF is a susceptibility gene for 
      schizophrenia in Chinese subjects.
FAU - Qian, Lulu
AU  - Qian L
AD  - Bio-X Center, Shanghai Jiao Tong University, Shanghai, China.
FAU - Zhao, Jian
AU  - Zhao J
FAU - Shi, Yongyong
AU  - Shi Y
FAU - Zhao, Xinzhi
AU  - Zhao X
FAU - Feng, Guoyin
AU  - Feng G
FAU - Xu, Feng
AU  - Xu F
FAU - Zhu, Shaomin
AU  - Zhu S
FAU - He, Lin
AU  - He L
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20061222
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Risk
MH  - Schizophrenia/*genetics
EDAT- 2007/01/02 09:00
MHDA- 2007/03/14 09:00
CRDT- 2007/01/02 09:00
PHST- 2006/12/02 00:00 [received]
PHST- 2006/12/12 00:00 [accepted]
PHST- 2007/01/02 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2007/01/02 09:00 [entrez]
AID - S0006-291X(06)02755-0 [pii]
AID - 10.1016/j.bbrc.2006.12.121 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 Feb 16;353(3):738-43. doi: 
      10.1016/j.bbrc.2006.12.121. Epub 2006 Dec 22.