PMID- 17197100
OWN - NLM
STAT- MEDLINE
DCOM- 20070521
LR  - 20240312
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 144
IP  - 4
DP  - 2007 Feb 23
TI  - Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor 
      mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or 
      controllable stress.
PG  - 1219-28
AB  - Neurotrophic factors, including basic fibroblast growth factor (FGF-2) and 
      brain-derived neurotrophic factor (BDNF) are known to be affected by exposure to 
      stressful experiences. Here, we examine the effects of behaviorally controllable 
      (escapable tailshock, ES) or uncontrollable (inescapable tailshock, IS) stress on 
      the expression of FGF-2 and BDNF mRNA in subregions of the medial prefrontal 
      cortex (mPFC) and the hippocampal formation (HF) of male Sprague-Dawley rats. ES 
      rats were placed in Plexiglas boxes equipped with a free spinning wheel and IS 
      rats were placed in identical boxes with the wheels fixed. ES and IS rats were 
      yoked such that they received the same tailshocks, but the ES rat could terminate 
      each shock for both rats. No stress controls (NS) remained in their home cages. 
      Rats were killed 0, 2, 24, or 72 h after termination of the stress session. In 
      situ hybridization was performed to measure FGF-2 and BDNF mRNA in the mPFC and 
      HF. In the mPFC, ES produced a significant increase in FGF-2 mRNA expression at 0 
      and 2 h post-stress. In the HF, ES produced a greater increase in FGF-2 mRNA 
      expression than IS and NS only in CA2. ES also produced an increase in BDNF mRNA 
      expression in the anterior cingulate at 0 h post-stress. No effects of stressor 
      controllability on BDNF were observed in the HF, although both ES and IS 
      decreased BDNF mRNA in the DG. FGF-2 in the mPFC may be involved in emotional 
      regulation ("coping") during stressful experiences.
FAU - Bland, S T
AU  - Bland ST
AD  - Department of Psychology and Center for Neuroscience, Campus Box 345, University 
      of Colorado, Boulder, CO 80309-0345, USA. sondra.bland@colorado.edu
FAU - Tamlyn, J P
AU  - Tamlyn JP
FAU - Barrientos, R M
AU  - Barrientos RM
FAU - Greenwood, B N
AU  - Greenwood BN
FAU - Watkins, L R
AU  - Watkins LR
FAU - Campeau, S
AU  - Campeau S
FAU - Day, H E
AU  - Day HE
FAU - Maier, S F
AU  - Maier SF
LA  - eng
GR  - R37 MH050479-14/MH/NIMH NIH HHS/United States
GR  - MH050479/MH/NIMH NIH HHS/United States
GR  - DA016004/DA/NIDA NIH HHS/United States
GR  - F32 DA016004/DA/NIDA NIH HHS/United States
GR  - K02 MH068016-04/MH/NIMH NIH HHS/United States
GR  - DA1319/DA/NIDA NIH HHS/United States
GR  - R01 MH050479/MH/NIMH NIH HHS/United States
GR  - R37 MH050479/MH/NIMH NIH HHS/United States
GR  - K02 MH068016/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061229
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Adaptation, Psychological/physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dentate Gyrus/metabolism/physiopathology
MH  - Electric Stimulation/adverse effects
MH  - Emotions/physiology
MH  - Fibroblast Growth Factor 2/*genetics
MH  - Gene Expression/physiology
MH  - Gyrus Cinguli/metabolism/physiopathology
MH  - Helplessness, Learned
MH  - Hippocampus/*metabolism/physiopathology
MH  - Male
MH  - Neural Pathways/metabolism/physiopathology
MH  - Neuropsychological Tests
MH  - Prefrontal Cortex/*metabolism/physiopathology
MH  - RNA, Messenger/*biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological/*metabolism/physiopathology
MH  - Up-Regulation/physiology
PMC - PMC1904349
MID - NIHMS18236
EDAT- 2007/01/02 09:00
MHDA- 2007/05/22 09:00
PMCR- 2008/02/23
CRDT- 2007/01/02 09:00
PHST- 2006/09/11 00:00 [received]
PHST- 2006/11/14 00:00 [revised]
PHST- 2006/11/16 00:00 [accepted]
PHST- 2007/01/02 09:00 [pubmed]
PHST- 2007/05/22 09:00 [medline]
PHST- 2007/01/02 09:00 [entrez]
PHST- 2008/02/23 00:00 [pmc-release]
AID - S0306-4522(06)01625-3 [pii]
AID - 10.1016/j.neuroscience.2006.11.026 [doi]
PST - ppublish
SO  - Neuroscience. 2007 Feb 23;144(4):1219-28. doi: 
      10.1016/j.neuroscience.2006.11.026. Epub 2006 Dec 29.