PMID- 17197922
OWN - NLM
STAT- MEDLINE
DCOM- 20070206
LR  - 20210102
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 31
IP  - 1
DP  - 2007 Jan
TI  - HLA-A, -B, -C expression in colon carcinoma mimics that of the normal colonic 
      mucosa and is prognostically relevant.
PG  - 76-84
AB  - Whether human leukocyte antigen (HLA)-A, -B, -C expression has any predictive 
      value on the prognosis of human malignancies remains controversial. Herein, 
      monoclonal antibodies with preferential reactivity for HLA-A, HLA-B, and HLA-C 
      (HCA2, HC10, and L31) were used to stain an archival collection of 291 
      formalin-fixed/paraffin-embedded tissues, comprising neoplastic lesions from 
      stages II and III colon carcinoma patients (n=165), and the uninvolved, 
      morphologically normal mucosae from a subset (n=126) of these patients. Marked 
      staining variability was detected not only in the tumors as in previous studies, 
      but also in the normal paired mucosae. HLA-A, -B, -C expression was similar in 
      approximately two thirds of the available 126 normal/neoplastic pairs, confirming 
      in vivo our previous observation that most tumor cells mimic the HLA phenotypes 
      of their normal counterparts. Both up and down-regulation occurred in the 
      remaining third of the pairs, but did not coincide with high and low expression, 
      respectively, conventionally evaluated on the tumor lesion only. Remarkably, a 
      "paired" evaluation, but not high or low expression in the tumor, was predictive 
      of the clinical outcome. Deviations from the expression in the normal paired 
      mucosa (both increases and decreases) of HCA2-reactive class I molecules 
      (possibly HLA-A), and down-regulation of L31-reactive class I molecules (possibly 
      HLA-C), particularly in tumors from stage II patients, correlated with poor 
      5-year overall and disease-free survival, hazard risk ranging from 2 to 6, 
      approximately. Thus, a paired immunohistochemical comparison reveals a novel 
      immune evasion strategy that may impact on the prognosis of colon carcinoma.
FAU - Benevolo, Maria
AU  - Benevolo M
AD  - Pathology Department, Regina Elena Cancer Institute CRS, Via delle Messi d'Oro 
      156, 00158 Rome, Italy.
FAU - Mottolese, Marcella
AU  - Mottolese M
FAU - Piperno, Giulia
AU  - Piperno G
FAU - Sperduti, Isabella
AU  - Sperduti I
FAU - Cione, Antonio
AU  - Cione A
FAU - Sibilio, Leonardo
AU  - Sibilio L
FAU - Martayan, Aline
AU  - Martayan A
FAU - Donnorso, Raffaele Perrone
AU  - Donnorso RP
FAU - Cosimelli, Maurizio
AU  - Cosimelli M
FAU - Giacomini, Patrizio
AU  - Giacomini P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adenocarcinoma/*metabolism/mortality/pathology/surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Colon/anatomy & histology/*metabolism
MH  - Colorectal Neoplasms/*metabolism/mortality/pathology/surgery
MH  - Female
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Intestinal Mucosa/anatomy & histology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survival Rate
EDAT- 2007/01/02 09:00
MHDA- 2007/02/07 09:00
CRDT- 2007/01/02 09:00
PHST- 2007/01/02 09:00 [pubmed]
PHST- 2007/02/07 09:00 [medline]
PHST- 2007/01/02 09:00 [entrez]
AID - 00000478-200701000-00009 [pii]
AID - 10.1097/01.pas.0000213343.55605.b9 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2007 Jan;31(1):76-84. doi: 10.1097/01.pas.0000213343.55605.b9.