PMID- 17198909
OWN - NLM
STAT- MEDLINE
DCOM- 20070315
LR  - 20090224
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 20
IP  - 1
DP  - 2007 Jan
TI  - The G-231A polymorphism in the endothelin-A receptor gene is associated with 
      lower aortic pressure in patients with dilated cardiomyopathy.
PG  - 32-7
AB  - BACKGROUND: The endothelin system (ES) plays an important role in blood pressure 
      (BP) regulation and also in the pathophysiology of idiopathic dilated 
      cardiomyopathy (DCM). Recently, we demonstrated that a genetic polymorphism in 
      the endothelin A (ET(A)) receptor gene was associated with survival in DCM 
      patients. The aim of this study was to determine whether polymorphisms in the 
      ET(A) receptor gene might be associated with the severity of DCM. METHODS: One 
      hundred twenty-four consecutively recruited unrelated patients with DCM, who 
      underwent a detailed phenotyping protocol, were genotyped for the ET(A) receptor 
      G-231A polymorphism using a hybridization technique with allele-specific 
      oligonucleotides. RESULTS: The exon 1 G-231A polymorphism of the ET(A) receptor 
      gene, upstream of the translation start site, was significantly associated with 
      directly measured intra-aortic pressure in that -231A allele carriers had 
      significantly lower systolic (P = .0043), as well as mean (P = .0016) and 
      diastolic (P = .0041) aortic pressure compared to noncarriers. The association of 
      ET(A) G-231A with aortic pressure was independent from other factors such as 
      prior medication, left ventricular end-diastolic diameter, age, gender, and New 
      York Heart Association (NYHA) functional classification. However, no such 
      association was seen for cuff BP and survival rates were not significantly 
      different between -231A allele carriers and -231G homozygotes (log rank test, P = 
      .66). No significant association with any other parameter investigated in the 
      present study could be observed, even when men and women were analyzed 
      separately. CONCLUSIONS: Our results suggest an association of genetic variation 
      in the ET(A) receptor gene with aortic pressure in patients with DCM.
FAU - Telgmann, Ralph
AU  - Telgmann R
AD  - Leibniz-Institute for Arteriosclerosis Research, Department of Molecular Genetics 
      of Cardiovascular Disease, University of Muenster, Domagkstrasse 3, D-48149 
      Muenster, Germany.
FAU - Harb, Bassam A
AU  - Harb BA
FAU - Ozcelik, Cemil
AU  - Ozcelik C
FAU - Perrot, Andreas
AU  - Perrot A
FAU - Schonfelder, Jacqueline
AU  - Schonfelder J
FAU - Nonnenmacher, Andreas
AU  - Nonnenmacher A
FAU - Brand, Marcus
AU  - Brand M
FAU - Schmidt-Petersen, Klaus
AU  - Schmidt-Petersen K
FAU - Dietz, Rainer
AU  - Dietz R
FAU - Kreutz, Reinhold
AU  - Kreutz R
FAU - Osterziel, Karl-Josef
AU  - Osterziel KJ
FAU - Paul, Martin
AU  - Paul M
FAU - Brand-Herrmann, Stefan-Martin
AU  - Brand-Herrmann SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Receptor, Endothelin A)
SB  - IM
MH  - Aged
MH  - Aorta/*physiopathology
MH  - Base Sequence
MH  - Blood Pressure/*genetics
MH  - Cardiomyopathy, Dilated/*genetics/physiopathology
MH  - Coronary Angiography
MH  - Exons
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Phenotype
MH  - Polymorphism, Single Nucleotide
MH  - Receptor, Endothelin A/*genetics
EDAT- 2007/01/03 09:00
MHDA- 2007/03/16 09:00
CRDT- 2007/01/03 09:00
PHST- 2006/03/17 00:00 [received]
PHST- 2006/06/21 00:00 [revised]
PHST- 2006/06/22 00:00 [accepted]
PHST- 2007/01/03 09:00 [pubmed]
PHST- 2007/03/16 09:00 [medline]
PHST- 2007/01/03 09:00 [entrez]
AID - S0895-7061(06)00474-2 [pii]
AID - 10.1016/j.amjhyper.2006.06.016 [doi]
PST - ppublish
SO  - Am J Hypertens. 2007 Jan;20(1):32-7. doi: 10.1016/j.amjhyper.2006.06.016.