PMID- 17199135
OWN - NLM
STAT- MEDLINE
DCOM- 20070716
LR  - 20070601
IS  - 1365-7852 (Print)
IS  - 1365-7852 (Linking)
VI  - 10
IP  - 2
DP  - 2007
TI  - Global analysis of differentially expressed genes in androgen-independent 
      prostate cancer.
PG  - 167-74
AB  - Progression to androgen independent (AI) is the main cause of death in prostate 
      cancer, and the mechanism is still unclear. By reviewing the expression profiles 
      of 26 prostate cancer samples in a holistic view, we found a group of genes 
      differentially expressed in AI compared with androgen-dependent groups 
      (P-value<0.01, t-test). Focusing on apoptosis, proliferation, hormone and 
      angiogenesis, we found a group of genes such as thioredoxin domain containing 5 , 
      tumor necrosis factor receptor superfamily, member 10a , ribosomal protein S19 
      and Janus kinase 2 upregulated in AI prostate cancer, could play important roles 
      in the transition from AD to AI and could be biomarkers of prognosis.
FAU - Wei, Q
AU  - Wei Q
AD  - State Key Laboratory of Genetic Engineering, Institute of Genetics, School of 
      Life Science, Fudan University, Shanghai, PR China.
FAU - Li, M
AU  - Li M
FAU - Fu, X
AU  - Fu X
FAU - Tang, R
AU  - Tang R
FAU - Na, Y
AU  - Na Y
FAU - Jiang, M
AU  - Jiang M
FAU - Li, Y
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070102
PL  - England
TA  - Prostate Cancer Prostatic Dis
JT  - Prostate cancer and prostatic diseases
JID - 9815755
RN  - 0 (Androgen Antagonists)
RN  - 0 (Androgens)
SB  - IM
MH  - Androgen Antagonists/pharmacology
MH  - Androgens/pharmacology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Male
MH  - Oligonucleotide Array Sequence Analysis
MH  - Prostatic Neoplasms/*genetics/*metabolism
EDAT- 2007/01/03 09:00
MHDA- 2007/07/17 09:00
CRDT- 2007/01/03 09:00
PHST- 2007/01/03 09:00 [pubmed]
PHST- 2007/07/17 09:00 [medline]
PHST- 2007/01/03 09:00 [entrez]
AID - 4500933 [pii]
AID - 10.1038/sj.pcan.4500933 [doi]
PST - ppublish
SO  - Prostate Cancer Prostatic Dis. 2007;10(2):167-74. doi: 10.1038/sj.pcan.4500933. 
      Epub 2007 Jan 2.