PMID- 17199493
OWN - NLM
STAT- MEDLINE
DCOM- 20070123
LR  - 20070103
IS  - 0003-1488 (Print)
IS  - 0003-1488 (Linking)
VI  - 230
IP  - 1
DP  - 2007 Jan 1
TI  - Response of feral cats to vaccination at the time of neutering.
PG  - 52-8
AB  - OBJECTIVE: To determine whether administration of inactivated virus or 
      modified-live virus (MLV) vaccines to feral cats at the time of neutering induces 
      protective serum antiviral antibody titers. DESIGN: Prospective study. ANIMALS: 
      61 feral cats included in a trap-neuter-return program in Florida. PROCEDURES: 
      Each cat received vaccines against feline panleukopenia virus (FPV), feline 
      herpes virus (FHV), feline calicivirus (FCV), FeLV, and rabies virus (RV). 
      Immediately on completion of surgery, vaccines that contained inactivated RV and 
      FeLV antigens and either MLV or inactivated FPV, FHV, and FCV antigens were 
      administered. Titers of antiviral antibodies (except those against FeLV) were 
      assessed in serum samples obtained immediately prior to surgery and approximately 
      10 weeks later. RESULTS: Prior to vaccination, some of the cats had protective 
      serum antibody titers against FPV (33%), FHV (21%), FCV (64%), and RV (3%). 
      Following vaccination, the overall proportion of cats with protective serum 
      antiviral antibody titers increased (FPV [90%], FHV [56%], FCV [93%], and RV 
      [98%]). With the exception of the FHV vaccine, there were no differences in the 
      proportions of cats protected with inactivated virus versus MLV vaccines. 
      CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that exposure to FPV, FHV, 
      and FCV is common among feral cats and that a high proportion of cats are 
      susceptible to RV infection. Feral cats appeared to have an excellent immune 
      response following vaccination at the time of neutering. Incorporation of 
      vaccination into trap-neuter-return programs is likely to protect the health of 
      individual cats and possibly reduce the disease burden in the community.
FAU - Fischer, Sarah M
AU  - Fischer SM
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      University of Florida, Gainesville, FL 32610, USA.
FAU - Quest, Cassie M
AU  - Quest CM
FAU - Dubovi, Edward J
AU  - Dubovi EJ
FAU - Davis, Rolan D
AU  - Davis RD
FAU - Tucker, Sylvia J
AU  - Tucker SJ
FAU - Friary, John A
AU  - Friary JA
FAU - Crawford, P Cynda
AU  - Crawford PC
FAU - Ricke, Teri A
AU  - Ricke TA
FAU - Levy, Julie K
AU  - Levy JK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Combined)
RN  - 0 (Vaccines, Inactivated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Animals, Wild
MH  - Antibodies, Viral/*blood
MH  - Castration/veterinary
MH  - Cat Diseases/*prevention & control
MH  - Cats/surgery
MH  - Female
MH  - Male
MH  - Prospective Studies
MH  - Time Factors
MH  - Vaccination/*veterinary
MH  - Vaccines, Combined/administration & dosage/immunology
MH  - Vaccines, Inactivated/administration & dosage/immunology
MH  - *Viral Vaccines/administration & dosage/immunology
MH  - Virus Diseases/prevention & control/*veterinary
EDAT- 2007/01/04 09:00
MHDA- 2007/01/24 09:00
CRDT- 2007/01/04 09:00
PHST- 2007/01/04 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2007/01/04 09:00 [entrez]
AID - 10.2460/javma.230.1.52 [doi]
PST - ppublish
SO  - J Am Vet Med Assoc. 2007 Jan 1;230(1):52-8. doi: 10.2460/javma.230.1.52.