PMID- 17199554
OWN - NLM
STAT- MEDLINE
DCOM- 20070306
LR  - 20070103
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 78
IP  - 1
DP  - 2007 Jan
TI  - Influence of the period after ovariectomy on femoral and mandibular bone density 
      and on induced periodontal disease.
PG  - 164-9
AB  - BACKGROUND: This study investigated the influence of the period after ovariectomy 
      on femoral and mandibular bone mineral density (BMD) and on induced periodontal 
      disease. METHODS: One hundred and twenty-six female Holtzman rats were divided 
      into nine groups: control, sham surgery (SHAM) with and without induction of 
      periodontal disease for 51 and 150 days, and ovariectomy (OVX) with and without 
      induction of periodontal disease for 51 and 150 days. Periodontal disease was 
      induced by placing ligatures on the first lower molars during the last 30 days of 
      each period. BMD was measured by dual-energy x-ray absorptiometry. Vertical bone 
      loss was determined by measuring the distance from the alveolar bone crest to the 
      cemento-enamel junction on the mesial side of the first lower molar. RESULTS: 
      Statistical analyses (Kruskal-Wallis test) revealed a significant difference 
      between the OVX and SHAM groups' global and femoral proximal epiphysis BMD (P 
      <0.001) for 150 days and in the global evaluation for 51 days. For mandibular 
      BMD, no difference was found between the groups of each period. Influence of the 
      period on femoral BMD was found only for the SHAM groups, with lower BMD for the 
      51-day period compared to the 150-day period (P <0.05). In the global evaluation 
      of the mandible, a lower BMD was found after 51 days. The period was a 
      contributing factor for the vertical bone loss, and it resulted in higher values 
      for the 51-day period (P <0.05). CONCLUSION: The period influenced the femoral 
      BMD and the vertical bone loss in induced periodontal disease.
FAU - Orrico, Silvana R P
AU  - Orrico SR
AD  - Department of Oral Diagnosis and Surgery, School of Dentistry of Araraquara, 
      State University of Sao Paulo, Araraquara, SP, Brazil. s-orrico@foar.unesp.br
FAU - Giro, Gabriela
AU  - Giro G
FAU - Goncalves, Daniela
AU  - Goncalves D
FAU - Takayama, Lilian
AU  - Takayama L
FAU - Pereira, Rosa M R
AU  - Pereira RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
SB  - IM
MH  - Alveolar Bone Loss/*etiology/physiopathology
MH  - Animals
MH  - Bone Density
MH  - Female
MH  - Femur/physiology
MH  - Mandible/physiology
MH  - Osteoporosis/*complications
MH  - Ovariectomy
MH  - Ovary/*physiology
MH  - Random Allocation
MH  - Rats
MH  - Statistics, Nonparametric
EDAT- 2007/01/04 09:00
MHDA- 2007/03/07 09:00
CRDT- 2007/01/04 09:00
PHST- 2007/01/04 09:00 [pubmed]
PHST- 2007/03/07 09:00 [medline]
PHST- 2007/01/04 09:00 [entrez]
AID - 10.1902/jop.2007.060136 [doi]
PST - ppublish
SO  - J Periodontol. 2007 Jan;78(1):164-9. doi: 10.1902/jop.2007.060136.