PMID- 17199743
OWN - NLM
STAT- MEDLINE
DCOM- 20070201
LR  - 20171116
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 57
IP  - 1
DP  - 2007 Jan
TI  - MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue 
      lymphomas.
PG  - 47-51
AB  - In view of the certain anatomic site-dependent frequency of chromosomal 
      translocations involved in extranodal marginal zone B cell lymphoma of 
      mucosa-associated lymphoid tissue (MALT lymphoma) pathogenesis, 17 salivary gland 
      MALT lymphoma cases were analyzed for MALT1 and FOXP1 translocations. B cell 
      CLL/lymphoma 10 (BCL10) and forkhead box PA (FOXP1) protein expression were 
      studied by immunohistochemistry and translocations identified using fluorescence 
      in situ hybridization (FISH)-specific probes FOXP1, t(11;18)(q21;q21)/API2-MALT1 
      and t(14;18)(q32;q21)/IgH-MALT1. None of the 11 analyzed cases showed FOXP1 
      rearrangement or amplification. The t(11;18) was present in five of 13 cases and 
      the t(14;18) in three of 13 cases. MALT1 translocations were mostly mutually 
      exclusive except in a single case. FOXP1 protein expression showed differences in 
      the proportion of tumor cells with nuclear expression but not in their intensity, 
      with the exception of one case where very intense nuclear staining was noted. 
      BCL10 nuclear expression was present in four of 17 cases, two of which lacked 
      t(11;18). Our results suggest that MALT1-specific translocations and FOXP1 
      rearrangements are not commonly involved in pathogenesis. A case with strong 
      FOXP1 protein expression indicates the possibility that the upregulation of FOXP1 
      expression is significant in a small subset of salivary gland MALT lymphomas. 
      Also a single case in which both MALT1 translocations were present indicates that 
      these are not always mutually exclusive.
FAU - Borovecki, Ana
AU  - Borovecki A
AD  - Department of Clinical Pathology and Cytology, Merkur University Hospital, 
      Zagreb, Croatia. anaborov@yahoo.com
FAU - Korac, Petra
AU  - Korac P
FAU - Ventura, Roland A
AU  - Ventura RA
FAU - Perisa, Marija Milkovic
AU  - Perisa MM
FAU - Banham, Alison H
AU  - Banham AH
FAU - Dominis, Mara
AU  - Dominis M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (B-Cell CLL-Lymphoma 10 Protein)
RN  - 0 (BCL10 protein, human)
RN  - 0 (FOXP1 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Repressor Proteins)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/genetics/*metabolism
MH  - B-Cell CLL-Lymphoma 10 Protein
MH  - Caspases/genetics/*metabolism
MH  - Forkhead Transcription Factors/genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/etiology/genetics/*metabolism/pathology
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - Repressor Proteins/genetics/*metabolism
MH  - Salivary Gland Neoplasms/etiology/genetics/*metabolism/pathology
MH  - Translocation, Genetic
MH  - Up-Regulation/genetics
EDAT- 2007/01/04 09:00
MHDA- 2007/02/03 09:00
CRDT- 2007/01/04 09:00
PHST- 2007/01/04 09:00 [pubmed]
PHST- 2007/02/03 09:00 [medline]
PHST- 2007/01/04 09:00 [entrez]
AID - PIN2056 [pii]
AID - 10.1111/j.1440-1827.2007.02056.x [doi]
PST - ppublish
SO  - Pathol Int. 2007 Jan;57(1):47-51. doi: 10.1111/j.1440-1827.2007.02056.x.