PMID- 17201166
OWN - NLM
STAT- MEDLINE
DCOM- 20070125
LR  - 20070104
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 26
IP  - 6B
DP  - 2006 Nov-Dec
TI  - Growth-suppressive function of phosphatidylethanolamine-binding protein in 
      anaplastic thyroid cancer.
PG  - 4437-42
AB  - BACKGROUND: A cDNA microarray analysis of anaplastic thyroid cancer cell lines 
      (ACL) was recently performed and the down-regulation of 
      phosphatidylethanolamine-binding protein (PBP) [RAF kinase inhibitor protein 
      (RKIP)] in ACL compared to normal thyroid tissues was identified. MATERIALS AND 
      METHODS: The expression levels of PBP in primary anaplastic and papillary thyroid 
      cancer, thyroid cancer cell lines (anaplastic, papillary and follicular) and 
      several normal human organs were examined. To examine the function of PBP, 
      cell-growth assays were performed. RESULTS: PBP expression was reduced in 
      anaplastic thyroid cancers, compared to either normal thyroid tissues or 
      differentiated thyroid cancers. PBP was expressed ubiquitously in normal human 
      tissues. Exogenous PBP expression suppressed ACL growth, and suggested a tumor 
      suppressive function of PBP in ACL. CONCLUSION: This is the first report 
      demonstrating that PBP may be a tumor suppressor whose loss is associated with 
      development of anaplastic thyroid cancer from differentiated thyroid cancer.
FAU - Akaishi, Junko
AU  - Akaishi J
AD  - Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 
      1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan. s4067@nms.ac.jp
FAU - Onda, Masamitsu
AU  - Onda M
FAU - Asaka, Shinichi
AU  - Asaka S
FAU - Okamoto, Junichi
AU  - Okamoto J
FAU - Miyamoto, Shizuyo
AU  - Miyamoto S
FAU - Nagahama, Mitsuji
AU  - Nagahama M
FAU - Ito, Kouichi
AU  - Ito K
FAU - Kawanami, Oichi
AU  - Kawanami O
FAU - Shimizu, Kazuo
AU  - Shimizu K
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Phosphatidylethanolamine Binding Protein)
SB  - IM
MH  - Cell Line, Tumor
MH  - Down-Regulation
MH  - Humans
MH  - Phosphatidylethanolamine Binding Protein/*physiology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Thyroid Neoplasms/*pathology
EDAT- 2007/01/05 09:00
MHDA- 2007/01/26 09:00
CRDT- 2007/01/05 09:00
PHST- 2007/01/05 09:00 [pubmed]
PHST- 2007/01/26 09:00 [medline]
PHST- 2007/01/05 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2006 Nov-Dec;26(6B):4437-42.