PMID- 17201721
OWN - NLM
STAT- MEDLINE
DCOM- 20070124
LR  - 20131121
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 47
IP  - 12
DP  - 2006 Dec
TI  - The frequency of reversible parkinsonism and cognitive decline associated with 
      valproate treatment: a study of 364 patients with different types of epilepsy.
PG  - 2183-5
AB  - PURPOSE: We report the frequency of parkinsonism and cognitive decline (P/CD) in 
      patients treated with valproate (VPA) after 1 year of treatment and at least 1 
      year of follow-up. METHODS: Three hundred sixty-four patients with various 
      epileptic syndromes and seizure types were treated with VPA mono- or polytherapy 
      for more than 1 year. RESULTS: We found five cases of P/CD (1.37%; 95% CI, 
      0.18-2.56%). Among 140 patients with different adverse effects (AEs) of VPA, P/CD 
      were among the rarest in frequency but significant in terms of drug 
      discontinuation (five of 17). CONCLUSIONS: Early identification of this type of 
      AE and discontinuation of the drug led to complete recovery in affected patients.
FAU - Ristic, Aleksandar J
AU  - Ristic AJ
AD  - Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia.
FAU - Vojvodic, Nikola
AU  - Vojvodic N
FAU - Jankovic, Slavko
AU  - Jankovic S
FAU - Sindelic, Aleksandra
AU  - Sindelic A
FAU - Sokic, Dragoslav
AU  - Sokic D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anticonvulsants/*adverse effects/therapeutic use
MH  - Cognition Disorders/*chemically induced/epidemiology
MH  - Drug Administration Schedule
MH  - Drug Therapy, Combination
MH  - Epilepsy/classification/diagnosis/*drug therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease, Secondary/*chemically induced/epidemiology
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Valproic Acid/*adverse effects/therapeutic use
EDAT- 2007/01/05 09:00
MHDA- 2007/01/25 09:00
CRDT- 2007/01/05 09:00
PHST- 2007/01/05 09:00 [pubmed]
PHST- 2007/01/25 09:00 [medline]
PHST- 2007/01/05 09:00 [entrez]
AID - EPI711 [pii]
AID - 10.1111/j.1528-1167.2006.00711.x [doi]
PST - ppublish
SO  - Epilepsia. 2006 Dec;47(12):2183-5. doi: 10.1111/j.1528-1167.2006.00711.x.