PMID- 17202130
OWN - NLM
STAT- MEDLINE
DCOM- 20070614
LR  - 20220331
IS  - 0022-2275 (Print)
IS  - 0022-2275 (Linking)
VI  - 48
IP  - 4
DP  - 2007 Apr
TI  - The role of TNF-alpha in chronic inflammatory conditions, intermediary 
      metabolism, and cardiovascular risk.
PG  - 751-62
AB  - The recent insight that inflammation contributes to the development of 
      atherosclerosis and type 2 diabetes mellitus constitutes a major breakthrough in 
      understanding the mechanisms underlying these conditions. In addition, it opens 
      the way for new therapeutic approaches that might eventually decrease the 
      prevalence of these public health problems. Tumor necrosis factor-alpha 
      (TNF-alpha) has been shown to play a key role in these processes and thus might 
      be a potential therapeutic target. Increased concentrations of TNF-alpha are 
      found in acute and chronic inflammatory conditions (e.g., trauma, sepsis, 
      infection, rheumatoid arthritis), in which a shift toward a proatherogenic lipid 
      profile and impaired glucose tolerance occurs. Although therapeutic blockade of 
      TNF-alpha worsens the prognosis in patients with abscesses and granulomatous 
      infections, this strategy is highly beneficial in the case of chronic 
      inflammatory conditions, including rheumatoid arthritis. Current investigations 
      assessing the impact of anti-TNF agents on intermediary metabolism suggest that 
      TNF-alpha blockade may improve insulin resistance and lipid profiles in patients 
      with chronic inflammatory diseases.
FAU - Popa, Calin
AU  - Popa C
AD  - Department of General Internal Medicine, Radboud University Nijmegen Medical 
      Center, Nijmegen, The Netherlands.
FAU - Netea, Mihai G
AU  - Netea MG
FAU - van Riel, Piet L C M
AU  - van Riel PL
FAU - van der Meer, Jos W M
AU  - van der Meer JW
FAU - Stalenhoef, Anton F H
AU  - Stalenhoef AF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070102
PL  - United States
TA  - J Lipid Res
JT  - Journal of lipid research
JID - 0376606
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Cardiovascular Diseases/*etiology
MH  - Chronic Disease
MH  - Humans
MH  - Inflammation/*etiology
MH  - *Lipid Metabolism
MH  - Risk
MH  - Tumor Necrosis Factor-alpha/*physiology
RF  - 114
EDAT- 2007/01/05 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/01/05 09:00
PHST- 2007/01/05 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/01/05 09:00 [entrez]
AID - S0022-2275(20)43428-5 [pii]
AID - 10.1194/jlr.R600021-JLR200 [doi]
PST - ppublish
SO  - J Lipid Res. 2007 Apr;48(4):751-62. doi: 10.1194/jlr.R600021-JLR200. Epub 2007 
      Jan 2.