PMID- 17202304
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20181113
IS  - 1556-6811 (Print)
IS  - 1556-679X (Electronic)
IS  - 1556-679X (Linking)
VI  - 14
IP  - 3
DP  - 2007 Mar
TI  - Effects of a diphtheria-tetanus-acellular pertussis vaccine on immune responses 
      in murine local lymph node and lung allergy models.
PG  - 211-9
AB  - We have previously shown that in mice, diphtheria-tetanus-acellular pertussis 
      (DTaP) vaccination before Bordetella pertussis infection resulted in, besides 
      effective clearance, immediate hypersensitivity (lung eosinophilia, increased 
      total serum immunoglobulin E [IgE], and increased ex vivo Th2 cytokine production 
      by cells from the bronchial lymph nodes). To better appreciate the extent of 
      these findings, we measured DTaP vaccination effects in the local lymph node 
      assay (LLNA) and an ovalbumin (OVA) lung allergy model. In the LLNA, mice were 
      vaccinated or adjuvant treated before being sensitized with trimellitic anhydride 
      (TMA; inducing a Th2-directed response) and dinitrochlorobenzene (DNCB; inducing 
      a Th1-directed response). Compared to the adjuvant-treated controls, the 
      vaccinated mice showed a decreased response to TMA and (to a much lesser extent) 
      an increased response to DNCB. The decreased response to TMA coincided with 
      increased transforming growth factor beta levels. With the exception of 
      filamentous hemagglutinin, all vaccine constituents contributed to the decreased 
      response to TMA. In the lung allergy model, sensitization induced OVA-specific 
      IgE, lung pathology (peribronchiolitis, perivasculitis, and hypertrophy of the 
      bronchiolar mucus cells) and increased the number of eosinophils, lymphocytes, 
      and neutrophils in the bronchoalveolar lavage fluid. Vaccination failed to 
      modulate these parameters. In conclusion, although DTaP vaccination may affect 
      the LLNA response, we found no evidence of an effect on lung allergy.
FAU - Vandebriel, Rob J
AU  - Vandebriel RJ
AD  - Laboratory for Toxicology, Pathology and Genetics, National Institute of Public 
      Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. 
      r.vandebriel@rivm.nl
FAU - Gremmer, Eric R
AU  - Gremmer ER
FAU - van Hartskamp, Michiel
AU  - van Hartskamp M
FAU - Dormans, Jan A M A
AU  - Dormans JA
FAU - Mooi, Frits R
AU  - Mooi FR
LA  - eng
PT  - Journal Article
DEP - 20070103
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Diphtheria-Tetanus-acellular Pertussis Vaccines)
RN  - 0 (Phthalic Anhydrides)
RN  - 0 (Transforming Growth Factor beta)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 80T61EUU7H (trimellitic anhydride)
SB  - IM
MH  - Animals
MH  - Diphtheria-Tetanus-acellular Pertussis Vaccines/*immunology
MH  - Female
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/blood
MH  - *Local Lymph Node Assay
MH  - Lung/*immunology/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Phthalic Anhydrides/immunology
MH  - Species Specificity
MH  - Transforming Growth Factor beta/biosynthesis
MH  - Vaccination
PMC - PMC1828861
EDAT- 2007/01/05 09:00
MHDA- 2007/09/26 09:00
PMCR- 2007/01/03
CRDT- 2007/01/05 09:00
PHST- 2007/01/05 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/01/05 09:00 [entrez]
PHST- 2007/01/03 00:00 [pmc-release]
AID - CVI.00306-06 [pii]
AID - 0306-06 [pii]
AID - 10.1128/CVI.00306-06 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2007 Mar;14(3):211-9. doi: 10.1128/CVI.00306-06. Epub 2007 
      Jan 3.