PMID- 17203192
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20161124
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 17
IP  - 2
DP  - 2007 Feb
TI  - Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese 
      population.
PG  - 483-8
AB  - Recent studies have proposed that susceptibility to chronic obstructive pulmonary 
      disease (COPD) might be related with the polymorphisms of some genes encoding 
      antioxidant enzymes, such as heme oxygenase-1 (HOX-1) and microsomal epoxide 
      hydrolase (mEPH). We examined these polymorphisms in 256 patients with COPD and 
      266 healthy smokers from Han population in Southwest China. The frequencies of 
      each allele were compared both individually and in combination between patients 
      and controls. Polymorphisms of HOX-1 gene could be grouped into three classes: S 
      (<or=25 repeat), M (26-31 repeat), and L (>or=32 repeat). The allele frequencies 
      of class L and the genotypic frequencies of the group with L were significantly 
      higher in COPD than in controls. Our findings also showed that the proportion of 
      slow mEPH activity was significantly higher in COPD than in controls. Conversely, 
      the proportion of fast mEPH activity was significantly lower in COPD. In combined 
      analysis, the frequency of the individuals having at least one L allele in the 
      HOX-1 gene promoter and slow or very slow activity genotype for mEPH was higher 
      in COPD than in control. Genetic polymorphisms in HOX-1 and mEPH genes are 
      associated with the development of COPD in Southwest China.
FAU - Fu, Wei-Ping
AU  - Fu WP
AD  - Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, 
      and Department of Respiratory Critical Care Medicine, The First Affiliated 
      Hospital of Kunming Medical College, 650091, P.R. China.
FAU - Sun, Chang
AU  - Sun C
FAU - Dai, Lu-Ming
AU  - Dai LM
FAU - Yang, Li-Fen
AU  - Yang LF
FAU - Zhang, Ya-Ping
AU  - Zhang YP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (DNA Primers)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - China
MH  - DNA Primers/chemistry
MH  - Epoxide Hydrolases/*genetics
MH  - Exons
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Heme Oxygenase-1/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Pulmonary Disease, Chronic Obstructive/*genetics
MH  - Sequence Analysis, DNA
EDAT- 2007/01/05 09:00
MHDA- 2007/03/30 09:00
CRDT- 2007/01/05 09:00
PHST- 2007/01/05 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2007/01/05 09:00 [entrez]
PST - ppublish
SO  - Oncol Rep. 2007 Feb;17(2):483-8.