PMID- 17204132
OWN - NLM
STAT- MEDLINE
DCOM- 20070427
LR  - 20230829
IS  - 1538-7933 (Print)
IS  - 1538-7836 (Linking)
VI  - 5
IP  - 3
DP  - 2007 Mar
TI  - Prognostic value of plasma tissue factor and tissue factor pathway inhibitor for 
      cardiovascular death in patients with coronary artery disease: the AtheroGene 
      study.
PG  - 475-82
AB  - BACKGROUND: Tissue factor (TF) and its specific inhibitor, tissue factor pathway 
      inhibitor (TFPI), are important contributors to the initiation of the coagulation 
      process. OBJECTIVES: To compare plasma levels of soluble TF (sTF) and free-TFPI 
      (f-TFPI) between patients with stable angina pectoris (SAP) and acute coronary 
      syndrome (ACS) and to assess the impact of the two variables on long-term 
      prognosis. PATIENTS/METHODS: Patients with SAPs (n = 1146) and acute coronary 
      syndrome (n = 523) from the AtheroGene study were included and followed for 2.3 
      years. Because of the strong impact of unfractionated heparin (UFH) on f-TFPI 
      levels, but not on sTF levels, patients having received UFH before blood drawing 
      were excluded from the analyses on f-TFPI (n = 226). RESULTS: On admission, no 
      significant differences in sTF levels were observed between SAP and ACS patients. 
      By comparison to patients with stable angina, f-TFPI levels significantly 
      increased in patients with acute unstable angina and further increased in 
      patients presenting with non-ST-elevation myocardial infarction and ST-elevation 
      myocardial infarction (P < 10(-4)). Among the 1669 individuals with a coronary 
      artery disease, 56 died from a cardiovascular cause. In prospective analyses, 
      high sTF levels were independently associated with an increased risk of 
      cardiovascular death in individuals with ACS (fully adjusted hazard ratio 
      associated with one quartile increase = 2.06; 95% confidence interval 1.24-3.45; 
      P = 0.006) but not in those with SAP (hazard ratio = 1.07; 95% confidence 
      interval 0.78-1.46; P = 0.67). In SAP and ACS patients, high f-TFPI levels were 
      not independently associated with an increased risk of cardiovascular death. 
      CONCLUSIONS: Plasma sTF levels were predictive of cardiovascular mortality in 
      individuals with ACS, whereas f-TFPI levels were associated with the severity of 
      myocardial damage on admission but were not independently related to outcome.
FAU - Morange, P E
AU  - Morange PE
AD  - INSERM, U626, Marseille, and Universite de la Mediterranee, Marseille, France. 
      pmorange@ap-hm.fr
FAU - Blankenberg, S
AU  - Blankenberg S
FAU - Alessi, M C
AU  - Alessi MC
FAU - Bickel, C
AU  - Bickel C
FAU - Rupprecht, H J
AU  - Rupprecht HJ
FAU - Schnabel, R
AU  - Schnabel R
FAU - Lubos, E
AU  - Lubos E
FAU - Munzel, T
AU  - Munzel T
FAU - Peetz, D
AU  - Peetz D
FAU - Nicaud, V
AU  - Nicaud V
FAU - Juhan-Vague, I
AU  - Juhan-Vague I
FAU - Tiret, L
AU  - Tiret L
CN  - Atherogene Investigators
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20070104
PL  - England
TA  - J Thromb Haemost
JT  - Journal of thrombosis and haemostasis : JTH
JID - 101170508
RN  - 0 (Biomarkers)
RN  - 0 (Lipoproteins)
RN  - 0 (lipoprotein-associated coagulation inhibitor)
RN  - 9035-58-9 (Thromboplastin)
SB  - IM
CIN - J Thromb Haemost. 2007 Mar;5(3):472-4. PMID: 17319902
MH  - Aged
MH  - Angina Pectoris/blood/mortality
MH  - Biomarkers/blood
MH  - Cardiovascular Diseases/*blood/etiology/*mortality
MH  - Cohort Studies
MH  - Coronary Stenosis/*blood/complications/*mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Germany/epidemiology
MH  - Humans
MH  - Lipoproteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/mortality
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Syndrome
MH  - Thromboplastin/*metabolism
MH  - Time Factors
EDAT- 2007/01/06 09:00
MHDA- 2007/04/28 09:00
CRDT- 2007/01/06 09:00
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/04/28 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
AID - S1538-7836(22)10132-7 [pii]
AID - 10.1111/j.1538-7836.2007.02372.x [doi]
PST - ppublish
SO  - J Thromb Haemost. 2007 Mar;5(3):475-82. doi: 10.1111/j.1538-7836.2007.02372.x. 
      Epub 2007 Jan 4.