PMID- 17204167
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 14
IP  - 6
DP  - 2006 Dec
TI  - [Karyotype analysis in 119 patients with chronic myeloid leukemia at blast 
      crisis].
PG  - 1074-8
AB  - To investigate the karyotype of chronic myeloid leukemia in blast crisis 
      (CML-BC), karyotype analysis was performed with R-banding technique in 119 
      patients with CML-BC. Dual fusion fluorescence in situ hybridization (FISH) was 
      used to detect derivative chromosome 9 deletions in randomly selected 28 cases of 
      them. The results showed that 11 cases (8.9%) were Ph negative; 113 cases (91.1%) 
      were Ph positive; 104 cases (83.9%) had standard Ph translocation; 9 cases (7.2%) 
      showed variant translocation, including 4 cases (3.2%) with simple variant 
      translocation and 5 cases (4.0%) with complex variant translocation. 72.6% of Ph 
      negative CML-BC had extra chromosomal abnormalities, with the most common ones 
      being i (17q) and +14. 72.3% of Ph positive CML-BC had extra cytogenetic changes 
      and +Ph, +8, i (17q) were the most frequent. The average time between diagnosis 
      and blast crisis was 29.0 months (range 2 to 66 months) for Ph negative cases and 
      34.2 months (range 1 to 127 months) for Ph positive cases. 5 cases (5/28, 17.9%) 
      with der (9) deletions were detected by FISH technique. It is concluded that 
      extra chromosomal abnormalities are common in CML-BC patients and FISH can 
      effectively detect the der (9) deletions.
FAU - Zhu, Yu
AU  - Zhu Y
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province People Hospital, Nanjing 210029, China.
FAU - Li, Jian-Yong
AU  - Li JY
FAU - Pan, Jin-Lan
AU  - Pan JL
FAU - Wu, Wei
AU  - Wu W
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Wu, Ya-Fang
AU  - Wu YF
FAU - Yang, Hui
AU  - Yang H
FAU - Zhang, Jian-Fu
AU  - Zhang JF
FAU - Chen, Li-Juan
AU  - Chen LJ
FAU - Xue, Yong-Quan
AU  - Xue YQ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - Adult
MH  - Blast Crisis/*genetics
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Male
EDAT- 2007/01/06 09:00
MHDA- 2007/12/21 09:00
CRDT- 2007/01/06 09:00
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
AID - 1009-2137(2006)06-1074-05 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Dec;14(6):1074-8.