PMID- 17204195
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 14
IP  - 6
DP  - 2006 Dec
TI  - [Prevalence of human herpesvirus-6 in allogeneic hematopoietic stem cell 
      transplant recipients in correlation with cytomegalovirus infection].
PG  - 1204-9
AB  - In order to study the prevalence of human herpesvirus 6 (HHV-6) in allogeneic 
      hematopoietic stem cell transplant (allo-HSCT) recipients in China and to analyze 
      the relationship between HHV-6 and cytomegalovirus (CMV) infection in post-HSCT 
      patients, nested polymerase chain reaction (PCR) was used to monitor HHV-6 
      DNAemia in 72 consecutive allo-HSCT recipients. 680 EDTA anticoagulated 
      peripheral blood specimens were gathered before HSCT or weekly until 12 weeks 
      after allo-HSCT. The variants of HHV-6 were identified by Hind III restriction 
      analysis. CMV-pp65 antigenemia was detected by immunofluorescence stain. The 
      results showed that HHV-6 DNAemia was detected at least once in 62.5% (45/72) of 
      the patients on the median day 14 (range, 7 - 63 days) after allo-HSCT, and 
      HHV-6B was the predominant variant. CMV antigenemia was detected at least once in 
      65.3% (47/72) of the patients on the median day 43 (range, 14 - 105 days) after 
      allo-HSCT. Co-infection of HHV-6 and CMV (HHV-6+/CMV+) occurred in 52.8% (38/72) 
      recipients. The onset of HHV-6 DNAemia was earlier than that of CMV antigenemia 
      (P < 0.0001). Patients with HHV-6 DNAemia positive were more likely to have 
      concurrent CMV antigenemia than HHV-6 DNAemia negative patients (84.4% vs 33.3%, 
      P = 0.0001) after allo-HSCT. Among the herpesvirus related disease, the 
      relatively high incidence of hemorrhage cystitis (HC) occurred in 23.6% (17/72) 
      of post-HSCT patients. 88.2% (15/17) of HC developed in HHV-6 positive patients, 
      and 82.3% (14/17) occurred in CMV+/HHV-6+ patients. It is concluded that 
      infection of HHV-6, co-infection of HHV-6 and CMV, commonly occurred in post-HSCT 
      patients in China, HHV-6 infection closely related to CMV antigenemia.
FAU - Wang, Li-Ru
AU  - Wang LR
AD  - Peking University Institute of hematology, Peking University People is Hospital, 
      Beijing 100044, China. wanglirumail@yahoo.com.cn
FAU - Dong, Lu-Jia
AU  - Dong LJ
FAU - Lu, Dao-Pei
AU  - Lu DP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - China/epidemiology
MH  - Cytomegalovirus/genetics/isolation & purification
MH  - Cytomegalovirus Infections/*complications/epidemiology
MH  - DNA, Viral/*blood/genetics
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Herpesvirus 6, Human/*isolation & purification/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Roseolovirus Infections/*complications/epidemiology/virology
EDAT- 2007/01/06 09:00
MHDA- 2007/12/21 09:00
CRDT- 2007/01/06 09:00
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
AID - 1009-2137(2006)06-1204-06 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Dec;14(6):1204-9.