PMID- 17204298
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20131121
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 218
IP  - 3
DP  - 2007 Feb 1
TI  - Atrazine-induced reproductive tract alterations after transplacental and/or 
      lactational exposure in male Long-Evans rats.
PG  - 238-48
AB  - Studies showed that early postnatal exposure to the herbicide atrazine (ATR) 
      delayed preputial separation (PPS) and increased incidence of prostate 
      inflammation in adult Wistar rats. A cross-fostering paradigm was used in this 
      study to determine if gestational exposure to ATR would also result in altered 
      puberty and reproductive tissue effects in the male rat. Timed-pregnant 
      Long-Evans (LE) rats were dosed by gavage on gestational days (GD) 15-19 with 100 
      mg ATR/kg body weight (BW) or 1% methylcellulose (controls, C). On postnatal day 
      (PND)1, half litters were cross-fostered, creating 4 treatment groups; C-C, 
      ATR-C, C-ATR, and ATR-ATR (transplacental-milk as source, respectively). On PND4, 
      male offspring in the ATR-ATR group weighed significantly less than the C-C 
      males. ATR-ATR male pups had significantly delayed preputial separation (PPS). 
      BWs at PPS for C-ATR and ATR-ATR males were reduced by 6% and 9%, respectively, 
      from that of C-C. On PND120, lateral prostate weights of males in the ATR-ATR 
      group were significantly increased over C-C. Histological examination of lateral 
      and ventral prostates identified an increased distribution of inflammation in the 
      lateral prostates of C-ATR males. By PND220, lateral prostate weights were 
      significantly increased for ATR-C and ATR-ATR, but there were no significant 
      changes in inflammation in either the lateral or ventral prostate. These results 
      suggest that in LE rats, gestational ATR exposure delays PPS when male offspring 
      suckle an ATR dam, but leads to increased lateral prostate weight via 
      transplacental exposure alone. Inflammation present at PND120 does not increase 
      in severity with time.
FAU - Rayner, Jennifer L
AU  - Rayner JL
AD  - Department of Environmental Sciences and Engineering, School of Public Health, 
      University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
FAU - Enoch, Rolondo R
AU  - Enoch RR
FAU - Wolf, Douglas C
AU  - Wolf DC
FAU - Fenton, Suzanne E
AU  - Fenton SE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20061123
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Herbicides)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - QJA9M5H4IM (Atrazine)
SB  - IM
MH  - *Abnormalities, Drug-Induced
MH  - Administration, Oral
MH  - Animals
MH  - Animals, Newborn
MH  - Animals, Suckling
MH  - Atrazine/*toxicity
MH  - Body Weight/drug effects
MH  - Female
MH  - Genitalia, Male/*drug effects/enzymology/pathology
MH  - Gonadal Steroid Hormones/blood
MH  - Herbicides/*toxicity
MH  - Lactation/*drug effects
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Organ Size/drug effects
MH  - Peroxidase/analysis/metabolism
MH  - Pituitary Gland/drug effects/pathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Long-Evans
EDAT- 2007/01/06 09:00
MHDA- 2007/03/30 09:00
CRDT- 2007/01/06 09:00
PHST- 2006/07/18 00:00 [received]
PHST- 2006/10/25 00:00 [revised]
PHST- 2006/11/03 00:00 [accepted]
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
AID - S0041-008X(06)00415-7 [pii]
AID - 10.1016/j.taap.2006.11.020 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2007 Feb 1;218(3):238-48. doi: 
      10.1016/j.taap.2006.11.020. Epub 2006 Nov 23.