PMID- 17204313
OWN - NLM
STAT- MEDLINE
DCOM- 20070509
LR  - 20070130
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 85
IP  - 4
DP  - 2006 Dec
TI  - Chronic mild stress inhibits BDNF protein expression and CREB activation in the 
      dentate gyrus but not in the hippocampus proper.
PG  - 842-9
AB  - Chronic stress is linked to development of depression and may trigger 
      neurobiological changes underlying the disease. Downregulation of the secretory 
      peptide brain-derived neurotrophic factor (BDNF) and the transcriptional 
      regulator calcium/cyclic-AMP responsive binding protein (CREB) have been 
      implicated in stress and depression-related pathology in animal studies. When 
      animals are exposed to the chronic mild stress (CMS) protocol, multiple 
      depression-like symptoms are observed. Here we investigated the effect of CMS on 
      BDNF protein expression and CREB activation in the dentate gyrus and hippocampus 
      proper. Rats exposed for 5 weeks to repeated, unpredictable, mild stressors 
      showed reduced BDNF expression and inhibited phosphorylation of CREB (Ser-133) in 
      the dentate gyrus (-25.0%+/-3.5% and -29.7+/-7.3%, respectively), whereas no 
      significant effects were observed in the hippocampus proper. CMS-treated rats 
      consumed less sucrose compared to control rats, indicating a state of anhedonia. 
      Moreover, phospho-CREB levels in the dentate gyrus were positively correlated 
      with the animals' sucrose intake at the end of the CMS protocol. These results 
      couple chronic mild stress to a downregulation of CREB activity and BDNF protein 
      expression specifically within the dentate gyrus and support the possibility that 
      the BDNF-CREB system plays an important role in the response to environmental 
      challenges.
FAU - Gronli, Janne
AU  - Gronli J
AD  - Department of Biomedicine, Section on Physiology, University of Bergen, Jonas 
      Lies vei 91, N-5009 Bergen, Norway. janne.gronli@biomed.uib.no
FAU - Bramham, Clive
AU  - Bramham C
FAU - Murison, Robert
AU  - Murison R
FAU - Kanhema, Tambudzai
AU  - Kanhema T
FAU - Fiske, Eldbjorg
AU  - Fiske E
FAU - Bjorvatn, Bjorn
AU  - Bjorvatn B
FAU - Ursin, Reidun
AU  - Ursin R
FAU - Portas, Chiara M
AU  - Portas CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070103
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Creb1 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 57-50-1 (Sucrose)
SB  - IM
MH  - Animals
MH  - Appetite Regulation
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Chronic Disease
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - Dentate Gyrus/*metabolism
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological/*metabolism
MH  - Sucrose/metabolism
EDAT- 2007/01/06 09:00
MHDA- 2007/05/10 09:00
CRDT- 2007/01/06 09:00
PHST- 2006/03/10 00:00 [received]
PHST- 2006/11/24 00:00 [revised]
PHST- 2006/11/28 00:00 [accepted]
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/05/10 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
AID - S0091-3057(06)00387-X [pii]
AID - 10.1016/j.pbb.2006.11.021 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2006 Dec;85(4):842-9. doi: 10.1016/j.pbb.2006.11.021. 
      Epub 2007 Jan 3.