PMID- 17204388
OWN - NLM
STAT- MEDLINE
DCOM- 20070629
LR  - 20191003
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 42
IP  - 4
DP  - 2007 Apr
TI  - Caloric restriction reduces age-related pseudocapillarization of the hepatic 
      sinusoid.
PG  - 374-8
AB  - Age-related changes in the hepatic sinusoid, called pseudocapillarization, may 
      contribute to the pathogenesis of dyslipidemia. Caloric restriction (CR) is a 
      powerful model for the study of aging because it extends lifespan. We assessed 
      the effects of CR on the hepatic sinusoid to determine whether 
      pseudocapillarization is preventable and hence a target for the prevention of 
      age-related dyslipidemia. Livers from young (6 months) and old (24 months) CR and 
      ad libitum fed (AL) F344 rats were examined using electron microscopy and 
      immunohistochemistry. In old age, there was increased thickness of the liver 
      sinusoidal endothelium and reduced endothelial fenestration porosity. In old CR 
      rats, endothelial thickness was less and fenestration porosity was greater than 
      in old AL rats. Immunohistochemistry showed that CR prevented age-related 
      decrease in caveolin-1 expression and increase in peri-sinusoidal collagen IV 
      staining, but did not alter the age-related increase of von Willebrand's factor. 
      CR reduces age-related pseudocapillarization of the hepatic sinusoid and 
      correlates with changes in caveolin-1 expression.
FAU - Jamieson, Hamish A
AU  - Jamieson HA
AD  - Centre for Education and Research on Ageing and ANZAC Medical Research Institute, 
      Concord Hospital, Concord, NSW, Australia.
FAU - Hilmer, Sarah N
AU  - Hilmer SN
FAU - Cogger, Victoria C
AU  - Cogger VC
FAU - Warren, Alessandra
AU  - Warren A
FAU - Cheluvappa, Rajkumar
AU  - Cheluvappa R
FAU - Abernethy, Darrell R
AU  - Abernethy DR
FAU - Everitt, Arthur V
AU  - Everitt AV
FAU - Fraser, Robin
AU  - Fraser R
FAU - de Cabo, Rafael
AU  - de Cabo R
FAU - Le Couteur, David G
AU  - Le Couteur DG
LA  - eng
GR  - Z99 AG999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070103
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Caveolin 1)
RN  - 0 (Collagen Type IV)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Caloric Restriction/*methods
MH  - Capillaries/ultrastructure
MH  - Caveolin 1/analysis
MH  - Collagen Type IV/analysis
MH  - Endothelial Cells/physiology/ultrastructure
MH  - Endothelium, Vascular/physiology/ultrastructure
MH  - Immunohistochemistry/methods
MH  - Liver/blood supply/*physiology/ultrastructure
MH  - Microscopy, Electron, Scanning/methods
MH  - Rats
MH  - Rats, Inbred F344
PMC - PMC1892153
MID - NIHMS20600
EDAT- 2007/01/06 09:00
MHDA- 2007/06/30 09:00
PMCR- 2007/06/15
CRDT- 2007/01/06 09:00
PHST- 2006/09/12 00:00 [received]
PHST- 2006/10/19 00:00 [revised]
PHST- 2006/11/03 00:00 [accepted]
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/06/30 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
PHST- 2007/06/15 00:00 [pmc-release]
AID - S0531-5565(06)00340-8 [pii]
AID - 10.1016/j.exger.2006.11.004 [doi]
PST - ppublish
SO  - Exp Gerontol. 2007 Apr;42(4):374-8. doi: 10.1016/j.exger.2006.11.004. Epub 2007 
      Jan 3.