PMID- 17204495
OWN - NLM
STAT- MEDLINE
DCOM- 20070516
LR  - 20220227
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 579
IP  - Pt 3
DP  - 2007 Mar 15
TI  - Maternal taurine supplementation in the late pregnant rat stimulates postnatal 
      growth and induces obesity and insulin resistance in adult offspring.
PG  - 823-33
AB  - An adequate supply of taurine during fetal life is important for normal beta-cell 
      development and insulin action. An altered availability of taurine may programme 
      glucose metabolism in utero and result in type 2 diabetes in adult age. We 
      examined whether maternal taurine supplementation in late pregnant rats affects 
      postnatal growth, adult body composition, insulin sensitivity and endogenous 
      insulin secretion in intrauterine growth restricted (IUGR) and normal offspring. 
      Uterine artery ligation or sham operations were performed on gestational day (GD) 
      19. Taurine supplementation was given to half of the dams from GD 18 until term, 
      resulting in four groups of offspring: sham (n = 22), sham/taurine (n = 22), IUGR 
      (n = 22) and IUGR/taurine (n = 24). The offspring were studied at 12 weeks of 
      age. In offspring with normal birth weight, fetal taurine supplementation 
      markedly stimulated postnatal growth. In sham/taurine females, fat depots, plasma 
      free fatty acid and leptin concentrations were increased, and insulin sensitivity 
      was reduced. Insulin sensitivity was unaltered in IUGR and IUGR/taurine 
      offspring. However, whereas IUGR offspring showed little catch-up growth, 50% of 
      IUGR/taurine animals displayed complete catch-up at 12 weeks of age, and these 
      animals had increased fat depots and reduced insulin sensitivity. In conclusion, 
      taurine supplementation in late gestation resulted in accelerated postnatal 
      growth, which was associated with adult obesity and insulin resistance in both 
      IUGR and normal offspring. This effect was particularly evident in females. These 
      data suggest that fetal taurine availability is an important determinant for 
      postnatal growth, insulin sensitivity and fat accumulation.
FAU - Hultman, Karin
AU  - Hultman K
AD  - Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Goteborg 
      University, Sweden. karin.hultman@neuro.gu.se
FAU - Alexanderson, Camilla
AU  - Alexanderson C
FAU - Manneras, Louise
AU  - Manneras L
FAU - Sandberg, Mats
AU  - Sandberg M
FAU - Holmang, Agneta
AU  - Holmang A
FAU - Jansson, Thomas
AU  - Jansson T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070104
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Leptin)
RN  - 1EQV5MLY3D (Taurine)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adipose Tissue/physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Body Composition
MH  - Body Weight
MH  - Female
MH  - Gestational Age
MH  - Glucose Clamp Technique
MH  - Hyperglycemia/physiopathology
MH  - Insulin Resistance/*physiology
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Leptin/blood
MH  - Lipid Metabolism/physiology
MH  - Maternal Nutritional Physiological Phenomena/drug effects
MH  - Obesity/physiopathology/*prevention & control
MH  - Placental Insufficiency/*drug therapy/physiopathology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Taurine/*pharmacology
PMC - PMC2151367
EDAT- 2007/01/06 09:00
MHDA- 2007/05/17 09:00
PMCR- 2008/03/15
CRDT- 2007/01/06 09:00
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/05/17 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
PHST- 2008/03/15 00:00 [pmc-release]
AID - jphysiol.2006.124610 [pii]
AID - 10.1113/jphysiol.2006.124610 [doi]
PST - ppublish
SO  - J Physiol. 2007 Mar 15;579(Pt 3):823-33. doi: 10.1113/jphysiol.2006.124610. Epub 
      2007 Jan 4.