PMID- 17204652
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20220330
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 315
IP  - 5808
DP  - 2007 Jan 5
TI  - Differential antigen processing by dendritic cell subsets in vivo.
PG  - 107-11
AB  - Dendritic cells (DCs) process and present self and foreign antigens to induce 
      tolerance or immunity. In vitro models suggest that induction of immunity is 
      controlled by regulating the presentation of antigen, but little is known about 
      how DCs control antigen presentation in vivo. To examine antigen processing and 
      presentation in vivo, we specifically targeted antigens to two major subsets of 
      DCs by using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the 
      cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, 
      are specialized for presentation on major histocompatibility complex (MHC) class 
      II. This difference in antigen processing is intrinsic to the DC subsets and is 
      associated with increased expression of proteins involved in MHC processing.
FAU - Dudziak, Diana
AU  - Dudziak D
AD  - Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 
      10021, USA.
FAU - Kamphorst, Alice O
AU  - Kamphorst AO
FAU - Heidkamp, Gordon F
AU  - Heidkamp GF
FAU - Buchholz, Veit R
AU  - Buchholz VR
FAU - Trumpfheller, Christine
AU  - Trumpfheller C
FAU - Yamazaki, Sayuri
AU  - Yamazaki S
FAU - Cheong, Cheolho
AU  - Cheong C
FAU - Liu, Kang
AU  - Liu K
FAU - Lee, Han-Woong
AU  - Lee HW
FAU - Park, Chae Gyu
AU  - Park CG
FAU - Steinman, Ralph M
AU  - Steinman RM
FAU - Nussenzweig, Michel C
AU  - Nussenzweig MC
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD)
RN  - 0 (CD8 Antigens)
RN  - 0 (DEC-205 receptor)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - *Antigen Presentation
MH  - Antigens, CD/analysis/immunology
MH  - Base Sequence
MH  - CD8 Antigens/analysis/immunology
MH  - Dendritic Cells/*immunology
MH  - Histocompatibility Antigens Class I/immunology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Lectins, C-Type/analysis/immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Minor Histocompatibility Antigens
MH  - Molecular Sequence Data
MH  - Oligonucleotide Array Sequence Analysis
MH  - Receptors, Cell Surface/analysis/immunology
MH  - T-Lymphocytes/immunology
EDAT- 2007/01/06 09:00
MHDA- 2007/01/17 09:00
CRDT- 2007/01/06 09:00
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
AID - 315/5808/107 [pii]
AID - 10.1126/science.1136080 [doi]
PST - ppublish
SO  - Science. 2007 Jan 5;315(5808):107-11. doi: 10.1126/science.1136080.