PMID- 17205291
OWN - NLM
STAT- MEDLINE
DCOM- 20070614
LR  - 20181113
IS  - 0179-0358 (Print)
IS  - 0179-0358 (Linking)
VI  - 23
IP  - 3
DP  - 2007 Mar
TI  - The protective effect of dexpanthenol on testicular atrophy at 60th day following 
      experimental testicular torsion.
PG  - 271-5
AB  - Despite the prompt diagnosis and treatment of testicular torsion (TT), there are 
      problems with fertility and atrophy after testicular salvage. Dexpanthenol (Dxp) 
      is the biologically active alcohol of pantothenic acid (PA). Dxp is converted to 
      PA in tissues. PA increases the content of reduced glutathione (GSH), Coenzyme A 
      and ATP synthesis in cells. GSH and glutathione-dependent peroxidases (GPX) are 
      the major defense systems against oxidative stress. GPX-4 is the major 
      antioxidant in testicular tissue. However, the activity of GPX-4 appeared and 
      increased only after puberty. We investigated the effect of Dxp on testicular 
      atrophy after TT at the 60th day. Rats were separated randomly into four groups. 
      Group C: control group, group Td: torsion + detorsion, group Sal: torsion + 
      saline + detorsion, group Dxp: torsion + Dxp + detorsion. The left testis was 
      rotated 720 degrees for 2 h. In group Sal, normal saline and in group Dxp, 
      Dexpanthenol were injected intraperitonally, 30 min before detorsion. After 60 
      days, the testicular weights and volumes were measured. Histopathology of the 
      left testis was evaluated with mean seminiferous tubular diameter (MSTD) and mean 
      testicular biopsy score (MTBS). The left (torsed) testicular weight and volume of 
      groups Td and Sal were significantly lower compared to group Dxp. The MSTD and 
      MTBS of group Td and Sal were significantly lower than group Dxp. Contralateral 
      testicular weight and volume of groups Td, Sal and Dxp had no significant 
      difference compared to the control group. Dxp significantly prevented testicular 
      atrophy after 60 days of TT. Dxp has FDA approval, is safe, cost effective and 
      readily available. Its relevance for clinical trials may especially be for the 
      problem of testicular atrophy catastrophe, seen very frequently following 
      testicular salvage.
FAU - Etensel, Barlas
AU  - Etensel B
AD  - Department of Pediatric Surgery, Adnan Menderes University, Aydin, Turkey. 
      betensel@adu.edu.tr
FAU - Ozkisacik, Sezen
AU  - Ozkisacik S
FAU - Ozkara, Esra
AU  - Ozkara E
FAU - Serbest, Yesim Aksu
AU  - Serbest YA
FAU - Oztan, Onur
AU  - Oztan O
FAU - Yazici, Mesut
AU  - Yazici M
FAU - Gursoy, Harun
AU  - Gursoy H
LA  - eng
PT  - Journal Article
DEP - 20070105
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 19F5HK2737 (Pantothenic Acid)
RN  - 1O6C93RI7Z (dexpanthenol)
SB  - IM
MH  - Animals
MH  - Atrophy/prevention & control
MH  - Male
MH  - Organ Size/drug effects
MH  - Pantothenic Acid/*analogs & derivatives/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Seminiferous Tubules/pathology
MH  - Spermatic Cord Torsion/drug therapy/*pathology
MH  - Testis/*pathology
EDAT- 2007/01/06 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/01/06 09:00
PHST- 2006/12/11 00:00 [accepted]
PHST- 2007/01/06 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/01/06 09:00 [entrez]
AID - 10.1007/s00383-006-1871-9 [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2007 Mar;23(3):271-5. doi: 10.1007/s00383-006-1871-9. Epub 2007 
      Jan 5.