PMID- 17205778
OWN - NLM
STAT- MEDLINE
DCOM- 20070515
LR  - 20220321
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 21
IP  - 124
DP  - 2006 Oct
TI  - [Biology of tumor necrosis factor type alpha (TNF-alpha)].
PG  - 358-61
AB  - Tumor necrosis factor type alpha (TNF-alpha) is one of 22 TNF superfamily 
      ligands. Its synthesis is regulated by expression of gene localized on chromosome 
      6. During posttranslation modification the proteolytic cleavage of the 
      76-aminoacid domain from the membrane-bound protein occurs with final formation 
      of mature, biologically active, secreted TNF-alpha form. The effect on the target 
      cells depends on the activation of specific surface receptors: TNFR1--is present 
      on most nuclear cells and has affinity to both membrane-bound and secreted forms; 
      TNFR2--is localized mostly on fibroblasts, endothelial cells, lymphocytes, 
      macrophages, neutrophils and thymocytes, and is activated almost selectively by 
      membrane-bound form. Depends on additional factors the TNFR1 activation may 
      initiate apoptosis, or activation of pathways which depend on nuclear factor 
      kappaB (NFkappaB) and c-Jun N-terminal kinase (JNK). Role of TNFR2 is unclear. 
      TNF-a has multidirectional biological activity that include immunomodulation, 
      oncostatic, osteolytic, pirogenic, proinflammatory and other effects.
FAU - Korobowicz, Agnieszka
AU  - Korobowicz A
AD  - Akademia Medyczna w Lublinie, II Katedra Pediatrii, Klinika Chorob Pluc i 
      Reumatologii Dzieciecej Dzieciecego Szpitala Klinicznego. 
      doktoragaimarek@neostrada.pl
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Biologia czynnika martwicy nowotworow typu alfa (TNF-alpha).
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases/metabolism
MH  - NF-kappa B/*metabolism
MH  - Receptors, Tumor Necrosis Factor/genetics/*metabolism
MH  - Signal Transduction/physiology
MH  - Tumor Necrosis Factor-alpha/*metabolism
RF  - 35
EDAT- 2007/01/09 09:00
MHDA- 2007/05/16 09:00
CRDT- 2007/01/09 09:00
PHST- 2007/01/09 09:00 [pubmed]
PHST- 2007/05/16 09:00 [medline]
PHST- 2007/01/09 09:00 [entrez]
PST - ppublish
SO  - Pol Merkur Lekarski. 2006 Oct;21(124):358-61.