PMID- 17206976
OWN - NLM
STAT- MEDLINE
DCOM- 20070424
LR  - 20141120
IS  - 1470-0328 (Print)
IS  - 1470-0328 (Linking)
VI  - 113 Suppl 3
DP  - 2006 Dec
TI  - Clinical practice evaluation of atosiban in preterm labour management in six 
      European countries.
PG  - 105-10
AB  - OBJECTIVE: To evaluate the efficacy and safety of early administration compared 
      with standard administration of atosiban, when predefined eligibility criteria 
      were met. DESIGN: A prospective, open-label, randomised clinical trial. Women 
      were randomised to receive atosiban either immediately (early) or when specified 
      criteria, in terms of duration/frequency of uterine contraction or status of 
      cervical dilation/effacement, were fulfilled (standard). SETTING: Carried out at 
      105 centres in six European countries. POPULATION: Pregnant women admitted to 
      hospital in threatened preterm labour between 24 and 34 weeks of gestation, 
      comprising a subgroup of women enrolled in the Tractocile Efficacy Assessment 
      Survey in Europe (TREASURE) clinical experience review. MAIN OUTCOME MEASURES: 
      Efficacy was defined as the successful delay of delivery with no alternative 
      tocolytic agent for 48 hours. RESULTS: More women in the early group remained 
      undelivered at 48 hours with no alternative tocolytic agent compared with those 
      who received atosiban when specified criteria were fulfilled (88.9 versus 76.1%; 
      P = 0.03). Safety was comparable between the groups. There were no statistical 
      differences in maternal, fetal or neonatal adverse events between the early and 
      standard atosiban arms. CONCLUSIONS: The use of atosiban was effective for the 
      delay of preterm labour and presented no safety concerns irrespective of the time 
      it was administered.
FAU - Husslein, P
AU  - Husslein P
AD  - Department of Obstetrics and Gynaecology, University of Vienna, General Hospital, 
      Vienna, Austria.
FAU - Roura, L C
AU  - Roura LC
FAU - Dudenhausen, J
AU  - Dudenhausen J
FAU - Helmer, H
AU  - Helmer H
FAU - Frydman, R
AU  - Frydman R
FAU - Rizzo, N
AU  - Rizzo N
FAU - Schneider, D
AU  - Schneider D
CN  - TREASURE study group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - BJOG
JT  - BJOG : an international journal of obstetrics and gynaecology
JID - 100935741
RN  - 0 (Tocolytic Agents)
RN  - 081D12SI0Z (atosiban)
RN  - W6S6URY8OF (Vasotocin)
SB  - IM
EIN - BJOG. 2008 Apr;115(5):674-5
MH  - Adolescent
MH  - Adult
MH  - Europe
MH  - Female
MH  - Humans
MH  - Labor Stage, First/drug effects
MH  - Obstetric Labor, Premature/*drug therapy
MH  - Pregnancy
MH  - Prospective Studies
MH  - Tocolytic Agents/adverse effects/*therapeutic use
MH  - Uterine Contraction/drug effects
MH  - Vasotocin/adverse effects/*analogs & derivatives/therapeutic use
EDAT- 2007/01/09 09:00
MHDA- 2008/03/26 09:00
CRDT- 2007/01/09 09:00
PHST- 2007/01/09 09:00 [pubmed]
PHST- 2008/03/26 09:00 [medline]
PHST- 2007/01/09 09:00 [entrez]
AID - BJO1134 [pii]
AID - 10.1111/j.1471-0528.2006.01134.x [doi]
PST - ppublish
SO  - BJOG. 2006 Dec;113 Suppl 3:105-10. doi: 10.1111/j.1471-0528.2006.01134.x.