PMID- 17207710
OWN - NLM
STAT- MEDLINE
DCOM- 20071010
LR  - 20081121
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 1
DP  - 2007 Jan
TI  - A high degree of HLA disparity arises from limited allelic diversity: analysis of 
      1775 unrelated bone marrow transplant donor-recipient pairs.
PG  - 30-40
AB  - The allelic diversity and associated human leukocyte antigen (HLA) disparity of 
      1775 bone marrow recipients and their unrelated donors, matched for six of six 
      (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, 
      -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analysis 
      included the class I (A, B, C) and II (DRB1, DQA1, DQB1, DPA1, DPB1) loci. Most 
      (>66%) of the predominantly Caucasian study population carried one or two of five 
      to seven common alleles at each HLA locus. In spite of this limited diversity, 
      29% of the six of six antigen-matched transplants carried allele mismatches at 
      HLA-A, -B, and/or -DRB1, and 92% carried at least one allele mismatch at one of 
      the eight HLA loci tested. Of the 968 HLA-A,-B,-DRB1 allele-matched pairs, 89% 
      carried mismatches at other HLA loci, predominantly at DP loci. The substantially 
      greater than expected HLA allelic disparity between donor and recipient suggests 
      extensive haplotypic diversity and underscores the importance of enhancing 
      approaches to mitigate the deleterious effect of HLA mismatches.
FAU - Hurley, Carolyn Katovich
AU  - Hurley CK
AD  - Department of Oncology, Georgetown University, Washington, DC, USA. 
      hurleyc@georgetown.edu
FAU - Fernandez-Vina, Marcelo
AU  - Fernandez-Vina M
FAU - Hildebrand, William H
AU  - Hildebrand WH
FAU - Noreen, Harriet J
AU  - Noreen HJ
FAU - Trachtenberg, Elizabeth
AU  - Trachtenberg E
FAU - Williams, Thomas M
AU  - Williams TM
FAU - Baxter-Lowe, Lee Ann
AU  - Baxter-Lowe LA
FAU - Begovich, Ann B
AU  - Begovich AB
FAU - Petersdorf, Effie
AU  - Petersdorf E
FAU - Selvakumar, Annamalai
AU  - Selvakumar A
FAU - Stastny, Peter
AU  - Stastny P
FAU - Hegland, Janet
AU  - Hegland J
FAU - Hartzman, Robert J
AU  - Hartzman RJ
FAU - Carston, Michael
AU  - Carston M
FAU - Gandham, Sharavi
AU  - Gandham S
FAU - Kollman, Craig
AU  - Kollman C
FAU - Nelson, Gene
AU  - Nelson G
FAU - Spellman, Stephen
AU  - Spellman S
FAU - Setterholm, Michelle
AU  - Setterholm M
LA  - eng
GR  - 240-97-0036/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20061025
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-D Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - *Alleles
MH  - Bone Marrow Transplantation/*immunology
MH  - *Genetic Variation
MH  - HLA Antigens/*genetics
MH  - HLA-D Antigens/genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Retrospective Studies
MH  - *Tissue Donors
EDAT- 2007/01/09 09:00
MHDA- 2007/10/11 09:00
CRDT- 2007/01/09 09:00
PHST- 2006/06/30 00:00 [received]
PHST- 2006/09/12 00:00 [revised]
PHST- 2006/09/28 00:00 [accepted]
PHST- 2007/01/09 09:00 [pubmed]
PHST- 2007/10/11 09:00 [medline]
PHST- 2007/01/09 09:00 [entrez]
AID - S0198-8859(06)00523-4 [pii]
AID - 10.1016/j.humimm.2006.09.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 Jan;68(1):30-40. doi: 10.1016/j.humimm.2006.09.004. Epub 2006 
      Oct 25.