PMID- 17207712
OWN - NLM
STAT- MEDLINE
DCOM- 20071010
LR  - 20070108
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 1
DP  - 2007 Jan
TI  - Impact of recipient HLA-C in liver transplant: a protective effect of HLA-Cw*07 
      on acute rejection.
PG  - 51-8
AB  - The involvement of the human leukocyte antigen (HLA) in liver graft acceptance is 
      controversial, but the frequency of acute rejection (AR) remains high in spite of 
      the use of the modern immunosuppressive agents. The present study was aimed at 
      determining whether an association exists between liver recipient HLA-C 
      polymorphism and AR development that could influence graft acceptance. Four 
      hundred and forty-six liver recipients and 473 controls were studied within the 
      framework of a collaborative study carried out by the Spanish Transplant 
      Immunotolerance Group (RED-GIT). HLA-A and -B were typed by the standard 
      microlymphocytotoxicity technique, and HLA-C by polymerase chain 
      reaction-sequence-specific oligonucleotide probes (PCR-SSOP). A statistically 
      significant decrease in the HLA-Cw*07 allele frequency was found in liver 
      recipients suffering AR episodes compared to those without AR (NAR). Studies 
      regarding the possible influence of the Asn80 and Lys80 epitopes showed that the 
      Asn80 epitope also could be associated with AR. However, further analysis 
      considering Asn80 alleles others than HLA-Cw*07, confirmed that the apparent 
      protective effect of the Asn80 epitope was actually from the HLA-Cw*07 allele. In 
      conclusion, the HLA-Cw*07 allele carried by the liver recipient is negatively 
      associated with AR development, and could be considered a predictive factor for 
      liver graft acceptance.
FAU - Moya-Quiles, Maria R
AU  - Moya-Quiles MR
AD  - Immunology Service, University Hospital Virgen de la Arrixaca, 30120 El Palmar, 
      Murcia, Spain.
FAU - Alvarez, Ruben
AU  - Alvarez R
FAU - Miras, Manuel
AU  - Miras M
FAU - Gomez-Mateo, Jorge
AU  - Gomez-Mateo J
FAU - Lopez-Alvarez, Maria R
AU  - Lopez-Alvarez MR
FAU - Marin-Moreno, Isabel
AU  - Marin-Moreno I
FAU - Martinez-Barba, Enrique
AU  - Martinez-Barba E
FAU - Sanchez-Mozo, Maria P S
AU  - Sanchez-Mozo MP
FAU - Gomez, Manuel
AU  - Gomez M
FAU - Arnal, Francisco
AU  - Arnal F
FAU - Sanchez-Bueno, Francisco
AU  - Sanchez-Bueno F
FAU - Marin, Luis A
AU  - Marin LA
FAU - Garcia-Alonso, Ana M
AU  - Garcia-Alonso AM
FAU - Minguela, Alfredo
AU  - Minguela A
FAU - Muro, Manuel
AU  - Muro M
FAU - Parrilla, Pascual
AU  - Parrilla P
FAU - Alonso, Clara
AU  - Alonso C
FAU - Alvarez-Lopez, Maria R
AU  - Alvarez-Lopez MR
CN  - Spanish Group of Transplant Immunology and Immunotolerance (G03/104)
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061113
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Acute Disease
MH  - Alleles
MH  - Female
MH  - Graft Rejection/genetics/*immunology/*prevention & control
MH  - HLA-C Antigens/*administration & dosage/*genetics/physiology
MH  - Humans
MH  - Liver Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retrospective Studies
EDAT- 2007/01/09 09:00
MHDA- 2007/10/11 09:00
CRDT- 2007/01/09 09:00
PHST- 2006/07/10 00:00 [received]
PHST- 2006/10/05 00:00 [revised]
PHST- 2006/10/13 00:00 [accepted]
PHST- 2007/01/09 09:00 [pubmed]
PHST- 2007/10/11 09:00 [medline]
PHST- 2007/01/09 09:00 [entrez]
AID - S0198-8859(06)00558-1 [pii]
AID - 10.1016/j.humimm.2006.10.009 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 Jan;68(1):51-8. doi: 10.1016/j.humimm.2006.10.009. Epub 2006 
      Nov 13.