PMID- 1720821 OWN - NLM STAT- MEDLINE DCOM- 19920110 LR - 20190817 IS - 0047-1828 (Print) IS - 0047-1828 (Linking) VI - 55 IP - 10 DP - 1991 Oct TI - Heart rate-dependent alteration of the frequency and coupling interval of ventricular arrhythmias as measured by 24-hour ECG monitoring. PG - 942-50 AB - Twenty-four hour ECG recordings of 132 patients with frequent (greater than 1000/day) ventricular premature contractions (VPCs) were analyzed using a computerized system, designed to evaluate the relationships between 1) the VPC frequency and heart rate (HR) (VPC-HR relation), 2) the coupling interval (CI) of VPCs and HR (CI-HR relation), and 3) the incidence of ventricular tachycardia (VT) and HR (VT-HR relation). The patterns of the VPC-HR relation included: 1) an increase in VPCs with increasing HR (positive correlation, 43 patients), 2) an increase in VPCs at low HR range and a decrease at high HR range, with increasing HR (bidirectional correlation, 74 patients), 3) a decrease in VPCs with increasing HR (negative correlation, 7 patients) and 4) constant VPCs over all HRs (flat correlation, 8 patients). Patients were divided into 2 broad categories according to whether they had a positive correlation (P group, 43 patients) or the other correlations (non-positive or NP group, 89 patients). Of 132 patients, the CI-HR relation was negative in 129 (98%) and positive in only 3 (2%). Patients with frequent VTs (10 or more events over 24h) were significantly more frequent in the P (9 patients, 21%) than in the NP group (7 patients, 8%, p less than 0.05). However, mean HR, mean CI, total VPC counts and the slope of CI-HR relation were not significantly different between the groups. The VT-HR relation observed in 16 patients with frequent VTs were positive in 9 of the P group and in 2 of the NP group and non-positive in 5 of the NP group.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Inoue, T AU - Inoue T AD - Department of Laboratory Medicine, Medical College of Oita, Japan. FAU - Koumatsu, K AU - Koumatsu K FAU - Ito, M AU - Ito M FAU - Arita, M AU - Arita M FAU - Saikawa, T AU - Saikawa T LA - eng PT - Journal Article PL - Japan TA - Jpn Circ J JT - Japanese circulation journal JID - 7806868 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Arrhythmias, Cardiac/*physiopathology MH - Cardiac Complexes, Premature/physiopathology MH - Chi-Square Distribution MH - *Electrocardiography, Ambulatory MH - Female MH - *Heart Rate MH - Humans MH - Male MH - Middle Aged MH - Regression Analysis MH - Reproducibility of Results MH - Signal Processing, Computer-Assisted MH - Tachycardia/physiopathology EDAT- 1991/10/01 00:00 MHDA- 1991/10/01 00:01 CRDT- 1991/10/01 00:00 PHST- 1991/10/01 00:00 [pubmed] PHST- 1991/10/01 00:01 [medline] PHST- 1991/10/01 00:00 [entrez] AID - 10.1253/jcj.55.942 [doi] PST - ppublish SO - Jpn Circ J. 1991 Oct;55(10):942-50. doi: 10.1253/jcj.55.942.