PMID- 17210520
OWN - NLM
STAT- MEDLINE
DCOM- 20070215
LR  - 20070109
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 127
IP  - 2
DP  - 2007 Feb
TI  - Reflex UroVysion testing of bladder cancer surveillance patients with equivocal 
      or negative urine cytology: a prospective study with focus on the natural history 
      of anticipatory positive findings.
PG  - 295-301
AB  - A proportion of patients under surveillance for recurrent bladder carcinoma with 
      no immediate evidence of bladder tumor recurrence have positive multitarget 
      fluorescence in situ hybridization (FISH; UroVysion, Vysis, Downers Grove, IL) 
      results. The course of these "anticipatory positive" cases and the time to 
      bladder tumor recurrence remains unknown. We followed up 250 patients with urine 
      cytologic results, concurrent multitarget FISH, and cystoscopic examination for 
      recurrent urothelial carcinoma. Of 81 cases (32.4%) with FISH-positive results, 
      tumor recurrence developed in 60 (74.0%). Of 169 (67.6%) FISH-negative cases, 
      recurrent urothelial carcinoma developed in 22 (13.0%). Of 211 patients (84.4%) 
      with negative cystoscopic examination results, 56 (26.5%) had positive FISH 
      results, and in 35 (62.5%) of these patients, recurrent urothelial carcinoma 
      developed. Approximately 27% of patients under bladder carcinoma surveillance 
      without immediate evidence of tumor recurrence will have a positive FISH result, 
      defining the anticipatory positive subset. In about 65% of this anticipatory 
      positive group, recurrent bladder urothelial carcinoma developed within 29 
      months.
FAU - Yoder, Brian J
AU  - Yoder BJ
AD  - Department of Anatomic and Clinical Pathology, Cleveland Clinic Foundation, 
      leveland, OH 44195, USA.
FAU - Skacel, Marek
AU  - Skacel M
FAU - Hedgepeth, Ryan
AU  - Hedgepeth R
FAU - Babineau, Denise
AU  - Babineau D
FAU - Ulchaker, James C
AU  - Ulchaker JC
FAU - Liou, Louis S
AU  - Liou LS
FAU - Brainard, Jennifer A
AU  - Brainard JA
FAU - Biscotti, Charles V
AU  - Biscotti CV
FAU - Jones, J Stephen
AU  - Jones JS
FAU - Tubbs, Raymond R
AU  - Tubbs RR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Cystoscopy
MH  - Cytodiagnosis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/diagnosis
MH  - Prospective Studies
MH  - Urinary Bladder Neoplasms/*diagnosis/urine
MH  - Urine/cytology
EDAT- 2007/01/11 09:00
MHDA- 2007/02/16 09:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/02/16 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - XNR033167N1023R4 [pii]
AID - 10.1309/ADJL7E810U1H42BJ [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2007 Feb;127(2):295-301. doi: 10.1309/ADJL7E810U1H42BJ.