PMID- 17211695
OWN - NLM
STAT- MEDLINE
DCOM- 20070403
LR  - 20220311
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 52
IP  - 2
DP  - 2007 Feb
TI  - Effect of antisecretory therapy on atypical symptoms in gastroesophageal reflux 
      disease.
PG  - 463-8
AB  - The effect of proton pump inhibitor (PPI) therapy on extraesophageal or atypical 
      manifestations of gastroesophageal reflux disease (GERD) remains unclear. This 
      study aimed to evaluate the prevalence of atypical manifestations in patients 
      with acid reflux disease and the effect of PPI treatment. Patients with symptoms 
      and signs suggestive of reflux were enrolled. Erosive esophagitis was stratified 
      using the Los Angeles classification. Demographic data and symptoms were assessed 
      using a questionnaire and included typical symptoms (heartburn, regurgitation, 
      dysphagia, odynophagia), and atypical symptoms (e.g., chest pain, sialorrhea, 
      hoarseness, globus sensation, chronic coughing, episodic bronchospasm, hiccup, 
      eructations, laryngitis, and pharyngitis). Symptoms were reassessed after a 
      3-month course of b.i.d. PPI therapy. A total of 266 patients with a first 
      diagnosis of GERD (erosive, 166; non-erosive, 100) were entered in the study. 
      Presentation with atypical symptoms was approximately equal in those with erosive 
      GERD and with non-erosive GERD, 72% vs 79% (P = 0.18). None of the study 
      variables showed a significant association with the body mass index. PPI therapy 
      resulted in complete symptom resolution in 69% (162/237) of the participants, 12% 
      (28) had improved symptoms, and 20% (47) had minimal or no improvement. We 
      conclude that atypical symptoms are frequent in patients with GERD. A trial of 
      PPI therapy should be considered prior to referring these patients to 
      specialists.
FAU - Dore, Maria Pina
AU  - Dore MP
AD  - Istituto di Clinica Medica, Universita di Sassari, Viale San Pietro 8, Sassari, 
      Italy. mpdore@uniss.it
FAU - Pedroni, Antonietta
AU  - Pedroni A
FAU - Pes, Gianni M
AU  - Pes GM
FAU - Maragkoudakis, Emanouil
AU  - Maragkoudakis E
FAU - Tadeu, Vincenza
AU  - Tadeu V
FAU - Pirina, Pietro
AU  - Pirina P
FAU - Realdi, Giuseppe
AU  - Realdi G
FAU - Delitala, Giuseppe
AU  - Delitala G
FAU - Malaty, Hoda M
AU  - Malaty HM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20070109
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Proton Pumps)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bronchial Spasm/etiology
MH  - Chest Pain/etiology
MH  - Cough/etiology
MH  - Enzyme Inhibitors/pharmacology/*therapeutic use
MH  - Eructation/etiology
MH  - Female
MH  - Gastroesophageal Reflux/*complications/*drug therapy/metabolism
MH  - Hiccup/etiology
MH  - Hoarseness/etiology
MH  - Humans
MH  - Italy/epidemiology
MH  - Laryngitis/etiology
MH  - Male
MH  - Middle Aged
MH  - Pharyngitis/etiology
MH  - Prevalence
MH  - *Proton Pump Inhibitors
MH  - Proton Pumps/metabolism
MH  - Severity of Illness Index
MH  - Sialorrhea/etiology
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2007/01/11 09:00
MHDA- 2007/04/04 09:00
CRDT- 2007/01/11 09:00
PHST- 2006/07/17 00:00 [received]
PHST- 2006/08/15 00:00 [accepted]
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/04/04 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - 10.1007/s10620-006-9573-7 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2007 Feb;52(2):463-8. doi: 10.1007/s10620-006-9573-7. Epub 2007 Jan 
      9.