PMID- 17212600
OWN - NLM
STAT- MEDLINE
DCOM- 20070306
LR  - 20220408
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 7
IP  - 6
DP  - 2006 Dec
TI  - Comprehensive assessment of postischemic vascular reactivity in Hispanic children 
      and adults with and without diabetes mellitus.
PG  - 329-35
AB  - BACKGROUND: To examine the whole postischemic hyperemic response period in 
      Hispanic children and adults with and without type 2 diabetes mellitus (T2DM) and 
      offer insight into the potential adaptive mechanisms involved in the arterial 
      response to disturbances in vascular homeostasis. METHODS: Ninety-eight adults 
      and 124 children of Hispanics participated in the study. Endothelial function was 
      assessed in the brachial artery using high-resolution ultrasonography (HRU). A 
      continuous scan was taken for 5 min during the hyperemic response, flow velocity 
      (FV) recordings and diameter measurements were obtained, and brachial arterial 
      blood flow (BF) was calculated after the cuff deflation. RESULTS: The increment 
      in FV during the reactive hyperemic period was higher in obese and in diabetic 
      children than in lean healthy children, although the time to reach peak brachial 
      artery diameter (BAD) and the per cent increase in peak diameter were comparable 
      in all three groups. In subjects with impaired glucose tolerance (IGT), the 
      hyperemic peak increase in FV was comparable to those in healthy adults. In 
      diabetic patients, the peak increase in BAD as well as the per cent increment in 
      the diameter were reduced at 50-60 s after the release of the arm cuff. The time 
      to reach the peak increase in diameter also was prolonged in diabetics when 
      compared with healthy adults. CONCLUSION: Our study demonstrates clear 
      differences in the normal vascular response between healthy children and healthy 
      adults and discloses the presence of additional abnormalities in the 
      flow-mediated vasodilation in diabetic and 'prediabetic' subjects.
FAU - Wajcberg, Estela
AU  - Wajcberg E
AD  - University of Texas Health Science Center and Texas Diabetes Institute, San 
      Antonio, TX 78229-3900, USA. ewajcberg@yahoo.com
FAU - Thoppil, Nimmi
AU  - Thoppil N
FAU - Patel, Shreya
AU  - Patel S
FAU - Fernandez, Marianella
AU  - Fernandez M
FAU - Hale, Daniel
AU  - Hale D
FAU - DeFronzo, Ralph
AU  - DeFronzo R
FAU - Cersosimo, Eugenio
AU  - Cersosimo E
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
SB  - IM
MH  - Adult
MH  - *Blood Flow Velocity
MH  - Brachial Artery/diagnostic imaging
MH  - Child
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Endothelium, Vascular/*diagnostic imaging
MH  - Hispanic or Latino
MH  - Humans
MH  - Hyperemia/diagnostic imaging/*epidemiology
MH  - Ischemia/diagnostic imaging/*physiopathology
MH  - Systole
MH  - Texas
MH  - Ultrasonography
EDAT- 2007/01/11 09:00
MHDA- 2007/03/07 09:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/03/07 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - PDI209 [pii]
AID - 10.1111/j.1399-5448.2006.00209.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2006 Dec;7(6):329-35. doi: 10.1111/j.1399-5448.2006.00209.x.