PMID- 17212683
OWN - NLM
STAT- MEDLINE
DCOM- 20070315
LR  - 20220321
IS  - 0333-1024 (Print)
IS  - 0333-1024 (Linking)
VI  - 27
IP  - 1
DP  - 2007 Jan
TI  - Oestrogen-modulated increase of calmodulin-dependent protein kinase II (CamKII) 
      in rat spinal trigeminal nucleus after systemic nitroglycerin.
PG  - 46-53
AB  - Migraine can be triggered by systemic administration of the nitric oxide (NO) 
      donor nitroglycerin (NTG) and by abrupt falls in plasma oestradiol. 
      Calmodulin-dependent protein kinase II (CamKII) present in superficial dorsal 
      horns is thought to play a role in sensitization of central nociceptors, a 
      phenomen present in migraineurs. We therefore examined in rats the expression of 
      CamKII in the caudal trigeminal nucleus (TNC) after subcutaneous NTG (10 mg/kg) 
      and its modulation by oestrogen. In male rats and in ovariectomized females, 
      after 4 h NTG increased significantly CamKII expression in the superficial layers 
      of TNC, but not in the upper thoracic spinal cord. NTG had no effect on CamKII 
      expression in oestradiol-treated ovariectomized animals. Thus NTG, i.e. NO, 
      selectively enhances CamKII in the rat TNC and oestradiol blocks this effect. 
      These data may help to understand the mechanisms by which NO triggers migraine 
      attacks and oestrogens influence migraine severity.
FAU - Pardutz, A
AU  - Pardutz A
AD  - Research Centre for Cellular & Molecular Neurobiology, University of Liege, 
      Liege, Belgium.
FAU - Hoyk, Z
AU  - Hoyk Z
FAU - Varga, H
AU  - Varga H
FAU - Vecsei, L
AU  - Vecsei L
FAU - Schoenen, J
AU  - Schoenen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
RN  - 0 (Drug Combinations)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - G59M7S0WS3 (Nitroglycerin)
SB  - IM
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Combinations
MH  - Enzyme Activation/drug effects
MH  - Estradiol/*administration & dosage
MH  - Female
MH  - Injections, Subcutaneous
MH  - Male
MH  - Nitric Oxide/*metabolism
MH  - Nitroglycerin/*administration & dosage
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Factors
MH  - Tissue Distribution/drug effects
MH  - Trigeminal Nucleus, Spinal/drug effects/*enzymology
EDAT- 2007/01/11 09:00
MHDA- 2007/03/16 09:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/03/16 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - CHA1244 [pii]
AID - 10.1111/j.1468-2982.2006.01244.x [doi]
PST - ppublish
SO  - Cephalalgia. 2007 Jan;27(1):46-53. doi: 10.1111/j.1468-2982.2006.01244.x.