PMID- 17212703
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 1
DP  - 2007 Jan
TI  - Molecular genetic studies of natives on Easter Island: evidence of an early 
      European and Amerindian contribution to the Polynesian gene pool.
PG  - 10-8
AB  - Most archaeological and linguistic evidence suggest a Polynesian origin of the 
      population of Easter Island (Rapanui), and this view has been supported by the 
      identification of Polynesian mitochondrial DNA (mtDNA) polymorphisms in 
      prehistoric skeletal remains. However, some evidence of an early South American 
      contact also exists (the sweet potato, bottle gourd etc.), but genetic studies 
      have so far failed to show an early Amerindian contribution to the gene pool on 
      Easter Island. To address this issue, we analyzed mtDNA and Y chromosome markers 
      and performed high-resolution human leukocyte antigen (HLA) genotyping of DNA 
      harvested from previously collected sera of 48 reputedly nonadmixed native Easter 
      Islanders. All individuals carried mtDNA types and HLA alleles previously found 
      in Polynesia, and most men carried Y chromosome markers of Polynesian origin, 
      providing further evidence of a Polynesian origin of the population of Easter 
      Island. A few individuals carried HLA alleles and/or Y chromosome markers of 
      European origin. More interestingly, some individuals carried the HLA alleles 
      A*0212 and B*3905, which are of typical Amerindian origin. The genealogy of some 
      of the individuals carrying these non-Polynesian HLA alleles and their haplotypic 
      backgrounds suggest an introduction into Easter Island in the early 1800s, or 
      earlier. Thus, there may have been an early European and Amerindian contribution 
      to the Polynesian gene pool of Easter Island.
FAU - Lie, B A
AU  - Lie BA
AD  - Institute of Immunology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, 
      Norway.
FAU - Dupuy, B M
AU  - Dupuy BM
FAU - Spurkland, A
AU  - Spurkland A
FAU - Fernandez-Vina, M A
AU  - Fernandez-Vina MA
FAU - Hagelberg, E
AU  - Hagelberg E
FAU - Thorsby, E
AU  - Thorsby E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *American Indian or Alaska Native
MH  - *Genetics, Population
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Pedigree
MH  - Polynesia/ethnology
MH  - *White People
EDAT- 2007/01/11 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/01/11 09:00
PHST- 2007/01/11 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/01/11 09:00 [entrez]
AID - TAN717 [pii]
AID - 10.1111/j.1399-0039.2006.00717.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Jan;69(1):10-8. doi: 10.1111/j.1399-0039.2006.00717.x.